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Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2012 by Xijing Hospital.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
Xijing Hospital Identifier:
First received: September 25, 2012
Last updated: September 29, 2012
Last verified: September 2012

Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.

Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied.

The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated.

Bypass Complications
Disorder of Blood Gas

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: The Difference Between Central and Peripheral Arterial Blood Oxygen Saturation in Patients Undergoing Cardiac Surgery With Different Cardiopulmonary Bypass Strategy

Further study details as provided by Xijing Hospital:

Primary Outcome Measures:
  • The difference between peripheral arterial oxygenation and aortic root blood oxygenation [ Time Frame: patients will be followed up during the cardiopulmonary bypass. Blood samples will be collected at 3 timepoints which is specified in the DESCRIPTION ]
    The three time points for blood sample collection are:1.right before clamping the aorta; 2.Three minutes after **** without ventilation;3.5 min after re-initiate mechanical ventilation.

Estimated Enrollment: 60
Study Start Date: October 2012
Estimated Study Completion Date: May 2013
Estimated Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Detailed Description:

All patients included will be assigned into two different groups according to the surgical approach,one group is named "NP" with normal perfusion,and the other is named "RP" with retrograde perfusion.

For all the patients,we will obtain 0.5ml blood from both peripheral arterial and aortic root for blood gas analysis at some specific time points.

We will focus on the differences of arterial oxygenation between peripheral arterial and aortic root at each group.At the same time,we will analyse the impact of artificial ventilation on it.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patient undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

Inclusion Criteria:

  • age > 18 years old
  • undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

  • without informed consent
  • pregnancy
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Please refer to this study by its identifier: NCT01698853

China, Shaanxi
Department of Anesthesiology, Xijing Hospital
Xi'an, Shaanxi, China, 710032
Sponsors and Collaborators
Xijing Hospital
Study Chair: Hailong Dong, Doctor department director
  More Information

Responsible Party: Xijing Hospital Identifier: NCT01698853     History of Changes
Other Study ID Numbers: 192837 
Study First Received: September 25, 2012
Last Updated: September 29, 2012 processed this record on February 20, 2017