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Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01698099
First Posted: October 2, 2012
Last Update Posted: October 2, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Sven Mueller, University Hospital Tuebingen
  Purpose

Hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. Therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis.

Methods:

All consecutive patients undergoing appendectomy for suspected appendicitis from May 2009 to August 2011 were analysed. Primary endpoint was the diagnostic accuracy of serum bilirubin levels to detect perforated appendicitis.


Condition
Appendicitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis

Resource links provided by NLM:


Further study details as provided by Sven Mueller, University Hospital Tuebingen:

Primary Outcome Measures:
  • Diagnostic accuracy of serum bilirubin [ Time Frame: 24h within initial presentation with clinical symptoms ]
    assessment of the diagnostic accuracy of hyperbilirubinemia (defined as serum bilirubin above 1.1 md/dl)


Enrollment: 500
Study Start Date: May 2009
Study Completion Date: September 2012
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 95 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients undergoing appendectomy for suspected appendicitis
Criteria

Inclusion Criteria:

  • all patients undergoing appendectomy for suspected appendicitis

Exclusion Criteria:

  • preexisting liver disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01698099


Locations
Germany
Departement of Visceral- and Transplant Surgery, University of Tuebingen
Tuebingen, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen
Investigators
Principal Investigator: Sven Müller, MD University Hospital Tuebingen
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Sven Mueller, Principal Investigator, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT01698099     History of Changes
Other Study ID Numbers: APP001
First Submitted: September 24, 2012
First Posted: October 2, 2012
Last Update Posted: October 2, 2012
Last Verified: September 2012

Additional relevant MeSH terms:
Appendicitis
Intraabdominal Infections
Infection
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Cecal Diseases
Intestinal Diseases
Bilirubin
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs