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Quantification and Description of the Increase in Serum Troponin Following Acute Coronary Syndrome (QUANTUM)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2012 by Université de Sherbrooke.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Université de Sherbrooke Identifier:
First received: September 28, 2012
Last updated: June 25, 2013
Last verified: September 2012
The new assay of troponins T (highly sensitive troponins) detects concentrations much lower than before. Few data are currently available on their kinetics during acute coronary syndrome, especially in regard to the correlation with CK MB. The aim of the present study is to describe the kinetic of highly sensitive troponins in acute coronary syndrome, to correlate it with the concentration of CK MB, and possibly to evaluate their prognostic value with respect to infarct size .

Acute Coronary Syndrome
Myocardial Infarction
Unstable Angina

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Quantification and Description of the Increase in Serum Troponin Following Acute Coronary Syndrome

Further study details as provided by Université de Sherbrooke:

Primary Outcome Measures:
  • Evaluation of troponins kinetic in acute coronary syndromes. [ Time Frame: 72 hours ]

Estimated Enrollment: 500
Study Start Date: June 2013
Estimated Study Completion Date: November 2013
Estimated Primary Completion Date: November 2013 (Final data collection date for primary outcome measure)
Detailed Description:

Patients who meet the inclusion criteria will have a highly sensitive troponins and CKMB assays q 8hr for the first day, and q 12h for the next 2 days. If clinically not indicated, the blood sample can be cancelled at any time, as in the case of a patient with an initial suspicion of acute coronary syndrome in which the final diagnosis is something else. Only patients with a definitive myocardial infarction will be analyzed.

Subgroup analyses includes ST-elevation MI, Non ST-elevation MI, revascularization vs no revascularization, procedural myocardial infarction.

Another analysis conducted is the correlation between the values of troponin and infarct size by echocardiography (in patients who have an echocardiography 2-7 days post AND 2-6 months post myocardial infarction)


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All consecutive patients presenting to the emergency department or being hospitalized for any reason in which we suspect an acute coronary syndrome.

Inclusion Criteria:

  • >= 18 years-old
  • Clinical suspicion of an acute coronary syndrome; (will be analyzed only patients with aposteriori definitive diagnosis of unstable angina or myocardial infarction)

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01698021

Contact: Paul Farand, MD MSc (819) 346-1110 ext 9093 pagette
Contact: Francis Bonenfant, resident (819) 346-1110 ext 4987 pagette

Canada, Quebec
Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Paul Farand, MD MSc    (819) 346-1110 ext 9093 pagette   
Contact: Francis Bonenfant, MD    (819) 346-1110 ext 4987   
Principal Investigator: Paul Farand, MD MSc         
Sponsors and Collaborators
Université de Sherbrooke
Principal Investigator: Paul Farand, Md MSc Centre de recherche du Centre hospitalier universitaire de Sherbrooke
  More Information

Responsible Party: Université de Sherbrooke Identifier: NCT01698021     History of Changes
Other Study ID Numbers: Projet 12-081
Study First Received: September 28, 2012
Last Updated: June 25, 2013

Keywords provided by Université de Sherbrooke:
Creatine Kinase, MB form
Acute coronary syndrome
myocardial infarction
Unstable angina

Additional relevant MeSH terms:
Myocardial Infarction
Acute Coronary Syndrome
Angina, Unstable
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Angina Pectoris
Chest Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 25, 2017