We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease? (DEMA)

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01695889
First Posted: September 28, 2012
Last Update Posted: March 25, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Anna-Karin Strand, MD, University Hospital, Linkoeping
  Purpose
The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records. The investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of Alzheimer´s disease.

Condition
Alzheimer´s Disease General Anesthesia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: A Case-control Study of Exposure to General Anesthesia and a Diagnosis of Alzheimer´s Disease Later in Life.

Resource links provided by NLM:


Further study details as provided by Anna-Karin Strand, MD, University Hospital, Linkoeping:

Primary Outcome Measures:
  • Exposure to general anesthesia [ Time Frame: Up to 20 years in retrospect ]

Secondary Outcome Measures:
  • Exposure to inhaled anesthetics [ Time Frame: Up to 20 years in retrospect ]

Enrollment: 877
Study Start Date: May 2012
Estimated Study Completion Date: July 2016
Estimated Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cases from a regional Alzheimer´s disease record. Matched controls from the national population register.
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer´s disease
  • Previous exposure to anesthesia

Exclusion Criteria:

  • Inability to retrieve medical records
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01695889


Locations
Sweden
University Hospital
Linkoping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
Investigators
Study Chair: Christina Eintrei, professor University Hospital Linkoping
  More Information

Responsible Party: Anna-Karin Strand, MD, Specialist in Anaesthesiology and Intensive Care, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01695889     History of Changes
Other Study ID Numbers: DEMA-1
First Submitted: September 27, 2012
First Posted: September 28, 2012
Last Update Posted: March 25, 2016
Last Verified: March 2016

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders