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Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease? (DEMA)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Anna-Karin Strand, MD, University Hospital, Linkoeping Identifier:
First received: September 27, 2012
Last updated: March 24, 2016
Last verified: March 2016
The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records. The investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of Alzheimer´s disease.

Alzheimer´s Disease General Anesthesia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: A Case-control Study of Exposure to General Anesthesia and a Diagnosis of Alzheimer´s Disease Later in Life.

Resource links provided by NLM:

Further study details as provided by Anna-Karin Strand, MD, University Hospital, Linkoeping:

Primary Outcome Measures:
  • Exposure to general anesthesia [ Time Frame: Up to 20 years in retrospect ]

Secondary Outcome Measures:
  • Exposure to inhaled anesthetics [ Time Frame: Up to 20 years in retrospect ]

Enrollment: 877
Study Start Date: May 2012
Estimated Study Completion Date: July 2016
Estimated Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cases from a regional Alzheimer´s disease record. Matched controls from the national population register.

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer´s disease
  • Previous exposure to anesthesia

Exclusion Criteria:

  • Inability to retrieve medical records
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01695889

University Hospital
Linkoping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
Study Chair: Christina Eintrei, professor University Hospital Linkoping
  More Information

Responsible Party: Anna-Karin Strand, MD, Specialist in Anaesthesiology and Intensive Care, University Hospital, Linkoeping Identifier: NCT01695889     History of Changes
Other Study ID Numbers: DEMA-1
Study First Received: September 27, 2012
Last Updated: March 24, 2016

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders processed this record on August 18, 2017