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Is There a Relationship Between Previous Exposure to General Anesthesia and the Development of Alzheimer´s Disease? (DEMA)

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ClinicalTrials.gov Identifier: NCT01695889
Recruitment Status : Active, not recruiting
First Posted : September 28, 2012
Last Update Posted : March 25, 2016
Information provided by (Responsible Party):
Anna-Karin Strand, MD, University Hospital, Linkoeping

Brief Summary:
The purpose of this study is to compare exposure to general anesthesia between cases with a diagnosis of Alzheimer´s disease and controls without diagnosis, through studies of medical records. The investigators wish to explore if there is a relationship between exposure to general anesthesia and the development of Alzheimer´s disease.

Condition or disease
Alzheimer´s Disease General Anesthesia

Study Type : Observational
Actual Enrollment : 877 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: A Case-control Study of Exposure to General Anesthesia and a Diagnosis of Alzheimer´s Disease Later in Life.
Study Start Date : May 2012
Estimated Primary Completion Date : July 2016
Estimated Study Completion Date : July 2016

Primary Outcome Measures :
  1. Exposure to general anesthesia [ Time Frame: Up to 20 years in retrospect ]

Secondary Outcome Measures :
  1. Exposure to inhaled anesthetics [ Time Frame: Up to 20 years in retrospect ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cases from a regional Alzheimer´s disease record. Matched controls from the national population register.

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer´s disease
  • Previous exposure to anesthesia

Exclusion Criteria:

  • Inability to retrieve medical records

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01695889

University Hospital
Linkoping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
Study Chair: Christina Eintrei, professor University Hospital Linkoping

Responsible Party: Anna-Karin Strand, MD, Specialist in Anaesthesiology and Intensive Care, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01695889     History of Changes
Other Study ID Numbers: DEMA-1
First Posted: September 28, 2012    Key Record Dates
Last Update Posted: March 25, 2016
Last Verified: March 2016

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders