Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer. (MPSORA)
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ClinicalTrials.gov Identifier: NCT01695161
Recruitment Status : Unknown
Verified February 2013 by Susanne Pitz, Johannes Gutenberg University Mainz. Recruitment status was: Recruiting
The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis-, Fabry-patients and healthy controls. We want to investigate biomechanical characteristics of the cornea and their influence on the IOP-measurements.
Corneal-Compensated Intraocular Pressure, Corneal Hysteresis and Corneal Resistance Factor Measurements Performed With the Ocular Response Analyzer and Their Correlation to Conventional Goldmann Applanation Tonometry.
Study Start Date :
Estimated Primary Completion Date :
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Ages Eligible for Study:
12 Years and older (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
25 eyes of MPS patients 25 eyes of Fabry patients 25 eyes of healthy age matched controls (a difference of ± 5 years in the mean between both groups is accepted)
MPS I, II, IV, VI patients with at least grade 3 of corneal clouding (Couprie et al.)
Fabry patients with cornea verticillata > grade 1
Age ≥ 12 years
Patient is able to comply with the study procedure
Patient has consented to be in the trial
Ability to fixate a target
History of corneal transplantation or refractive surgery
Corneal pathologies other than MPS-associated corneal opacity