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Trial record 54 of 5353 for:    "Depressive Disorder" [DISEASE] AND Behavioral

Cognitive Control Training as an Adjunct to Behavioral Activation Therapy in the Treatment of Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01694719
Recruitment Status : Unknown
Verified September 2012 by Samantha Moshier, M.A., Boston University.
Recruitment status was:  Recruiting
First Posted : September 27, 2012
Last Update Posted : September 27, 2012
Information provided by (Responsible Party):
Samantha Moshier, M.A., Boston University

Brief Summary:
The purpose of this study is to evaluate the potential effects of a cognitive training program when combined with a particular form of psychotherapy (behavioral activation therapy) for depression. Behavioral activation therapy targets changes in behavior as a method for improving a depressed individual's thoughts, feelings, and overall quality of life. This study is designed to test whether a computerized brain exercise called cognitive control training can enhance the effects of a 5-session behavioral activation therapy program. CCT has been shown to reduce depressive symptoms in two other studies, but it has not yet been combined with behavioral activation therapy. The investigators hypothesize that individuals assigned to the behavioral activation plus cognitive control training condition will demonstrate reduced depressive symptoms from pre to post treatment compared with those assigned to the behavioral activation plus computerized control condition. The investigators hypothesize that these gains will be maintained at one-month follow up.

Condition or disease Intervention/treatment Phase
Depression Behavioral: Brief Behavioral Activation Treatment for Depression Behavioral: Cognitive Control Training Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 26 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Study Start Date : September 2012
Estimated Primary Completion Date : October 2013
Estimated Study Completion Date : October 2013

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Behavioral Activation + Cognitive Control Training
Participants will receive 5 sessions of behavioral activation therapy concurrent with 4 sessions of cognitive control training, a computerized intervention which targets cognitive control processes such as working memory and attention.
Behavioral: Brief Behavioral Activation Treatment for Depression
Behavioral: Cognitive Control Training
Active Comparator: Behavioral Activation Therapy plus Control Task
Participants will receive 5 sessions of behavioral activation therapy and 4 sessions of a non-active, computerized control task.
Behavioral: Brief Behavioral Activation Treatment for Depression

Primary Outcome Measures :
  1. Beck Depression Inventory

Secondary Outcome Measures :
  1. Montgomery Asberg Depression Rating Scale

Other Outcome Measures:
  1. Ruminative Response Scale

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Adults ages 18-65
  2. Primary psychiatric diagnosis of major depressive disorder
  3. Ability to read and speak English sufficiently to complete study procedures
  4. If taking antidepressant or anxiolytic medication, participants must be taking a stabilized dose for a minimum period of at least 8 weeks prior to entry into the study
  5. Willingness and ability to comply with the requirements of the study protocol

Exclusion Criteria:

  1. Lifetime history of bipolar disorder or psychotic disorder
  2. Neurological disorder such as Parkinson's disease or traumatic brain injury
  3. Alcohol or substance dependence within the past 6 months
  4. Substantial suicide risk
  5. Concurrent psychotherapy initiated within 2 months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of the depression other than general supportive therapy
  6. Current use of antipsychotics, stimulants, or modafinil

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01694719

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Contact: Samantha J Moshier, M.A. 617-358-4311
Contact: Michael W Otto, Ph.D. 617-353-9610

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United States, Massachusetts
Boston University - Translational Research Program Recruiting
Boston, Massachusetts, United States, 02215
Contact: Samantha Moshier, M.A.    617-358-4311   
Sponsors and Collaborators
Boston University

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Responsible Party: Samantha Moshier, M.A., Doctoral Candidate in Psychology, Boston University Identifier: NCT01694719     History of Changes
Other Study ID Numbers: 2930
First Posted: September 27, 2012    Key Record Dates
Last Update Posted: September 27, 2012
Last Verified: September 2012

Keywords provided by Samantha Moshier, M.A., Boston University:
Major Depressive Disorder
Behavioral Activation
Cognitive Training

Additional relevant MeSH terms:
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Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders