QT Interval in Patients With Pacemaker Dependency (QT-TENDENCY)
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The aim of this study is to examine a correction term for an adapted QT interval during ventricular pacing (right, left and biventricular pacing) to obtain valid formulae correcting for the QT intervals in various pacing conditions.
Condition or disease
High Degree AV-blockLeft Bundle Branch Block
This investigation aims at determining a possibility to assess the usefulness of various formulae that correct for the different effects of various pacing modes on the QT interval. More specifically, the hypothesis will be tested that applying adequate correction will preserve the predictive power of the QT-interval regarding proarrhythmia in various cardiac pathologies and therapies.
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The study will enroll 180 patients after an implantation of cardioverter/defibrillator or pacemaker based on a standard guideline indication. The point of enrolment for all patients is the time at which the patient signs and dates the ICF during the hospital stay in the context of implantation.
implanted cardioverter/defibrillator or pacemaker
negative pregnancy test for women of child bearing potential
stable function of the implanted device
stable medical therapy relating to the underlying disease
stable medical therapy of antiarrhythmic drugs and other QT-time changing drugs
no instability of rhythm
x-ray of thorax during device implantation in two levels (ap and ll axis)
written informed consent
coronary heart disease and angina pectoris symptoms
patient with acute myocardial infarction or CABG while the last 4 weeks
patient with tachycardia and a rest frequency >80 bpm