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Pseudoexfoliation and Chronic Kidney Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01693744
First Posted: September 26, 2012
Last Update Posted: September 26, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Leyla Niyaz, Corum State Hospital
  Purpose

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.


Condition
Chronic Kidney Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Relationship Between Pseudoexfoliation and Chronic Kidney Disease

Resource links provided by NLM:


Further study details as provided by Leyla Niyaz, Corum State Hospital:

Primary Outcome Measures:
  • Prevalance of pseudoexfoliation in patients with chronic kidney disease [ Time Frame: 7 months ]

Enrollment: 358
Study Start Date: October 2011
Study Completion Date: April 2012
Groups/Cohorts
Dialysis patients
Patients with stage 5 chronic kidney disease undergoing haemodialysis
Chronic kidney disease patients
Stage 1-4 Chronic kidney disease patients
Control group
Patients with normal renal functions

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients from nephrology clinic
Criteria

Inclusion Criteria:

  • All patients with chronic kidney disease stage 1-5

Exclusion Criteria:

  • History of eye trauma or surgery
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01693744


Locations
Turkey
Corum State Hospital
Corum, Turkey, 19000
Sponsors and Collaborators
Corum State Hospital
Investigators
Principal Investigator: Leyla Niyaz, M.D. Specialist in Ophthalmology
  More Information

Responsible Party: Leyla Niyaz, Ophthalmology Specialist, Corum State Hospital
ClinicalTrials.gov Identifier: NCT01693744     History of Changes
Other Study ID Numbers: LNiyaz
First Submitted: September 20, 2012
First Posted: September 26, 2012
Last Update Posted: September 26, 2012
Last Verified: September 2012

Keywords provided by Leyla Niyaz, Corum State Hospital:
Pseudoexfoliation, chronic kidney disease

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency