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Pseudoexfoliation and Chronic Kidney Disease

This study has been completed.
Information provided by (Responsible Party):
Leyla Niyaz, Corum State Hospital Identifier:
First received: September 20, 2012
Last updated: September 24, 2012
Last verified: September 2012

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Chronic Kidney Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Relationship Between Pseudoexfoliation and Chronic Kidney Disease

Resource links provided by NLM:

Further study details as provided by Leyla Niyaz, Corum State Hospital:

Primary Outcome Measures:
  • Prevalance of pseudoexfoliation in patients with chronic kidney disease [ Time Frame: 7 months ]

Enrollment: 358
Study Start Date: October 2011
Study Completion Date: April 2012
Dialysis patients
Patients with stage 5 chronic kidney disease undergoing haemodialysis
Chronic kidney disease patients
Stage 1-4 Chronic kidney disease patients
Control group
Patients with normal renal functions


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients from nephrology clinic

Inclusion Criteria:

  • All patients with chronic kidney disease stage 1-5

Exclusion Criteria:

  • History of eye trauma or surgery
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Please refer to this study by its identifier: NCT01693744

Corum State Hospital
Corum, Turkey, 19000
Sponsors and Collaborators
Corum State Hospital
Principal Investigator: Leyla Niyaz, M.D. Specialist in Ophthalmology
  More Information

Responsible Party: Leyla Niyaz, Ophthalmology Specialist, Corum State Hospital Identifier: NCT01693744     History of Changes
Other Study ID Numbers: LNiyaz
Study First Received: September 20, 2012
Last Updated: September 24, 2012

Keywords provided by Leyla Niyaz, Corum State Hospital:
Pseudoexfoliation, chronic kidney disease

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency processed this record on August 23, 2017