Cyanobacteria Allergy in Lake Kineret

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by Meir Medical Center.
Recruitment status was  Not yet recruiting
Yigal Allon Kinneret Limnological Laboratory
Information provided by (Responsible Party):
Ronit Confino-Cohen, Meir Medical Center Identifier:
First received: September 19, 2012
Last updated: September 23, 2012
Last verified: September 2012

People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake`s water . The symptoms are compatible with immediate allergic reaction. Previous reports suggested a connection between similar symptoms and contact with different cyanobacteria (living in fresh water lakes). In this study we intend to prove the mechanism of these reactions. To prove the exact allergen that causes allergic rhinitis allergists perform skin tests with different suspected allergens. Likewise, we would like to perform skin tests to different proteins extracted from cyanobacteria collected in lake Kineret.

Condition Intervention
Nasal Stuffiness
Procedure: Skin test with sterile extracts of different cyanobacteria

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Cyanobacteria Allergy in Lake Kineret

Resource links provided by NLM:

Further study details as provided by Meir Medical Center:

Primary Outcome Measures:
  • Reproducibility of skin test to cyanobacteria [ Time Frame: Immediately after performing the test (15 minutes) ] [ Designated as safety issue: No ]

Estimated Enrollment: 200
Study Start Date: November 2012
Estimated Study Completion Date: November 2014
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Skin test with sterile extracts of different cyanobacteria
    Skin test with sterile extracts of different cyanobacteria is performed on the volar aspect of the forearm. Typically, the results are read 15 minutes after performing the test. Test is regarded as positive when wheal of more than 3mm and flare appear within this time frame. Positive test indicates the existence of specific IgE to the extract in on skin mast cells .

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age above 18
  • exposed to Lake Keneret water by swiming or sirfing

Exclusion Criteria:

  • age under 18
  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01693198

Contact: Ronit Confino-Cohen, MD 97297472811
Contact: Arnon Goldberg, MD 97297472717

Meir medical center Not yet recruiting
Kfar-Saba, Israel
Contact: Ronit Confino-Cohen, MD   
Contact: Arnon Goldberg, MD   
Principal Investigator: Ronit Confino-Cohen, MD         
Sub-Investigator: Arnon Goldberg, MD         
Sponsors and Collaborators
Meir Medical Center
Yigal Allon Kinneret Limnological Laboratory
  More Information

No publications provided

Responsible Party: Ronit Confino-Cohen, MD, Meir Medical Center Identifier: NCT01693198     History of Changes
Other Study ID Numbers: 0172-12-MMC
Study First Received: September 19, 2012
Last Updated: September 23, 2012
Health Authority: Israel : Institutional Review Board

Keywords provided by Meir Medical Center:
sweet water swimming processed this record on March 25, 2015