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Cyanobacteria Allergy in Lake Kineret

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2012 by Ronit Confino-Cohen, Meir Medical Center.
Recruitment status was:  Not yet recruiting
Yigal Allon Kinneret Limnological Laboratory
Information provided by (Responsible Party):
Ronit Confino-Cohen, Meir Medical Center Identifier:
First received: September 19, 2012
Last updated: September 23, 2012
Last verified: September 2012
People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake`s water . The symptoms are compatible with immediate allergic reaction. Previous reports suggested a connection between similar symptoms and contact with different cyanobacteria (living in fresh water lakes). In this study we intend to prove the mechanism of these reactions. To prove the exact allergen that causes allergic rhinitis allergists perform skin tests with different suspected allergens. Likewise, we would like to perform skin tests to different proteins extracted from cyanobacteria collected in lake Kineret.

Condition Intervention
Nasal Stuffiness Sneezing Itching Procedure: Skin test with sterile extracts of different cyanobacteria

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Cyanobacteria Allergy in Lake Kineret

Resource links provided by NLM:

Further study details as provided by Ronit Confino-Cohen, Meir Medical Center:

Primary Outcome Measures:
  • Reproducibility of skin test to cyanobacteria [ Time Frame: Immediately after performing the test (15 minutes) ]

Estimated Enrollment: 200
Study Start Date: November 2012
Estimated Study Completion Date: November 2014
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Skin test with sterile extracts of different cyanobacteria
    Skin test with sterile extracts of different cyanobacteria is performed on the volar aspect of the forearm. Typically, the results are read 15 minutes after performing the test. Test is regarded as positive when wheal of more than 3mm and flare appear within this time frame. Positive test indicates the existence of specific IgE to the extract in on skin mast cells .

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age above 18
  • exposed to Lake Keneret water by swiming or sirfing

Exclusion Criteria:

  • age under 18
  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01693198

Contact: Ronit Confino-Cohen, MD 97297472811
Contact: Arnon Goldberg, MD 97297472717

Meir medical center Not yet recruiting
Kfar-Saba, Israel
Contact: Ronit Confino-Cohen, MD   
Contact: Arnon Goldberg, MD   
Principal Investigator: Ronit Confino-Cohen, MD         
Sub-Investigator: Arnon Goldberg, MD         
Sponsors and Collaborators
Meir Medical Center
Yigal Allon Kinneret Limnological Laboratory
  More Information

1. Carmichael W. A world overview—One-hundred-twentyseven years of research on toxic cyanobacteria—Where do we go from here? Adv Exp Med Biol 2008;619:105-125 2. Petrus M, Culerrier R, Campistron M, Barre A, Rouge P. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. AL L ERGY (AllergyNet) 2010; 65 : 924-932N 3. Torokne A, Palovics A, and Bankine M. Allergenic (sensitization, skin and eye Irritation).Effects of freshwater Cyanobacteria—experimental evidence. Environ Toxicol 2001; 16: 512-516 4.Alster, A., Kaplan-Levy, R., Sukenik, A. & Zohary, T. Morphology and phylogeny of a non-toxic invasive Cylindrospermopsis raciborskii from a Mediterranean Lake. Hydrobiologia 2010; 639, 115-128. 5.Banker, R., Carmeli, S., Hadas, O., Teltsch, B., Porat, R. & Sukenik, A. Identification of cylindrospermopsin in Aphanizomenon ovalisporum (Cyanophyceae) isolated from Lake Kinneret, Israel. Journal of Phycology 1997; 33, 613-616. 6.Hadas, O., Pinkas, R., Malinsky-Rushansky, N., Nishri, A., Kaplan, A., Rimmer, A. & Sukenik, A. Appearance and establishment of diazotrophic cyanobacteria in Lake Kinneret, Israel. Freshwater Biology 2012; 57, 1214-1227. 7. Bernstein JA, Ghosh D, Levin LS, Zheng S, Carmichael W, Lummus Z, Bernstein IL. Cyanobacteria: an unrecognized ubiquitous sensitizing allergen? Allergy Asthma Proc. 2011;32:106-110 8.Törökné, A., Asztalos, M., Bánkiné, M., Bickel, H., Borbély, G., Carmeli, S., Codd, G.A., Fastner, J., Huang, Q., Humpage, A., Metcalf, J.S., Rábai, E., Sukenik, A., Surányi, G., Vasas, G. & Weiszfeiler, V. Interlaboratory comparison trial on cylindrospermopsin measurement. Analytical Biochemistry 2004; 332, 280-284. 9.Lawton, L.A., Edwards, C. & Codd, G.A. Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 1994; 119, 1525-1530

Responsible Party: Ronit Confino-Cohen, MD, Meir Medical Center Identifier: NCT01693198     History of Changes
Other Study ID Numbers: 0172-12-MMC
Study First Received: September 19, 2012
Last Updated: September 23, 2012

Keywords provided by Ronit Confino-Cohen, Meir Medical Center:
sweet water swimming

Additional relevant MeSH terms:
Immune System Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Interleukin 1 Receptor Antagonist Protein
Antirheumatic Agents processed this record on September 21, 2017