MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01692561|
Recruitment Status : Completed
First Posted : September 25, 2012
Last Update Posted : April 27, 2018
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||22 participants|
|Official Title:||Study Title: Brain Transmitters/Metabolites, Magnetic Resonance Spectroscopy, and Brain Connectivity: Diagnostic Strategies to Study the Effects of Non-Pharmacologic Therapies for Dysautonomia and Chronic Nausea|
|Actual Study Start Date :||August 2012|
|Actual Primary Completion Date :||June 11, 2013|
|Actual Study Completion Date :||June 11, 2013|
Healthy subjects without symptoms of dysautonomia.
Fainting due to sudden drop in blood pressure.
Sudden decrease in blood pressure while standing.
Postural Orthostatic Tachycardic Syndrome
Increased heart rate when standing.
- Assessment of the implication of dysautonomia on the brain and better evaluate its potential mechanistic process. [ Time Frame: Assessments will occur in a one and a half hour visit. ]The first objective of the proposed project is to study central transmitter/metabolite profiles using in vivo 1H Magnetic Resonance Spectroscopy (MRS) in children with dysautonomia diagnosed by tilt table testing compared to healthy children without symptoms of dysautonomia. The second objective will be to determine whether dysautonomia associated with nausea and cardiovascular instability shares common alterations in brain networks. We will be using cognitive and sensory processing tasks based on our prior experience with both traditional fMRI and network analyses.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01692561
|United States, North Carolina|
|Wake Forest University Baptist Medical Center|
|Winston-Salem, North Carolina, United States, 27157|
|Principal Investigator:||Debra Diz, M.D.||Wake Forest University Health Sciences|