MRI Study of Stomach Volumes and Satiety
|Healthy||Dietary Supplement: Study test meal 1 Dietary Supplement: Study test meal 2 Dietary Supplement: Study test meal 3|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Basic Science
|Official Title:||Effects of Test Meal Volume and Energy Density on Gastric Volumes and Satiety Assessed by MRI|
- Total gastric content half emptying time T50 [ Time Frame: 0 - 240 mins ]Total gastric volume at half the experimental time
- Volumes of test meal in the stomach [ Time Frame: 0 - 240 mins ]gastric volumes of the test meals in the stomach obtained from MRI images, as a function of time
- Relationship of gastric behaviour of test meal stomach volumes with satiety [ Time Frame: 0 - 240 minutes ]A comparison of the gastric volumes with satiety scores obtained throughout the experiment
|Study Start Date:||December 2010|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Experimental: Study test meal 1
High volume, high energy density test meal. Volunteers will be given 490 mL of a high energy test meal once in the morning
Dietary Supplement: Study test meal 1
Volunteers will be fed with a high volume, high energy density test meal.
Experimental: Study test meal 2
High volume, low energy density test meal. Volunteers will be given 490 mL of a high volume low energy density test meal once in the morning
Dietary Supplement: Study test meal 2
Volunteers will be fed with a high volume, low energy density test meal
Experimental: Study test meal 3
A low volume, high energy test meal. Volunteers will be given 140 mL high energy density test meal once in the morning.
Dietary Supplement: Study test meal 3
Volunteers will be fed with a low volume, high energy density test meal
The tone of the proximal stomach decreases on meal intake through a process of gastric accommodation, aimed at increasing the capacity of the stomach. An increased gastric volume progressively distends the stomach, and this distension has been shown to have an inverse relationship on appetite. The link is assumed to be based on activation of mechanoreceptors lying in the walls of the stomach. On activation, vagal discharges are triggered, leading to activation of hypothalamic neurons and regulation of feelings of satiety. Gasrtric emptying is also regulated by duodenal feedback mechanisms triggered by the arrival and amount of nutrients.
Based on current knowledge, a high volume test meal would be expected to produce more gastric distension and satiety over a low volume test meal, and a low energy density food would be expected to empty from the stomach faster than a high energy density food. Going on this premise, study test meal 2 would be expected to empty faster than study test meal 1. These phenomena will be investigated using non invasive Magnetic Resonance Imaging (MRI) methods. MRI can measure gastric volumes serially and non-invasively with high spatial resolution. Ultimately, the findings from this study will provide novel insights on mechanisms of gastric distension and satiety.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01690182
|Unilever Research and Development|
|Olivier van Noortlann 120, AT Vlaardingen, Netherlands, 3133|
|Nottingham Digestive Diseases Centre and Sir Peter Mansfield Magnetic Resonance Centre|
|University of Nottingham, Nottingham, United Kingdom, NG7 2RD|
|Principal Investigator:||Luca Marciani, PhD||University of Nottingham|