The Effect of PXR Activation on Blood Pressure Regulation
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We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.
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Ages Eligible for Study:
18 Years to 40 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
BMI 19-30 kg/m2
Age 18-40 years
Systolic blood pressure 95 - 140 mmHg
Any continuous medication
Any significant medical condition as judged by the study physician
Diastolic blood pressure over 90 mmHg
Sensitivity to rifampicin
Pregnancy and lactation
Abuse of alcohol or medications, or drug use.
Participation in other trial with medications in previous 30 days