Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
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|ClinicalTrials.gov Identifier: NCT01690039|
Recruitment Status : Recruiting
First Posted : September 21, 2012
Last Update Posted : November 28, 2016
- To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.
- To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.
|Condition or disease||Intervention/treatment|
|Acidosis, Renal Tubular Nephrolithiasis Vacuolar Proton-Translocating ATPases||Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers|
|Study Start Date :||September 2012|
|Estimated Primary Completion Date :||September 2017|
|Estimated Study Completion Date :||September 2017|
All study participants
Furosemide-Fludrocortisone-Test and Ammonium chloride-Loading Test will be performed in renal stone patients.
Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.
Other Name: Application of Furosemide (Lasix® ) and Fludrocortisone (Florinef®)
- Capability of urinary acidification [ Time Frame: Five to six hours ]
- Polymorphisms in the ATP6V1 gene [ Time Frame: 12 months ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01690039
|Contact: Daniel Fuster, Attending physician Nephrology||++41 (0)31 631 37 firstname.lastname@example.org|
|Contact: Nasser Dhayat, Resident Nephrology||++41 (0)31 632 31 email@example.com|
|Department of Nephrology and Hypertension, Bern University Hospital||Recruiting|
|Bern, Switzerland, 3010|
|Principal Investigator: Fuster Daniel, Attending physician Nephrology|
|Sub-Investigator: Nasser Dhayat, Resident Nephrology|
|Principal Investigator:||Daniel Fuster, Attending physician Nephrology||Department of Nephrology and Hypertension, Bern University Hospital|