Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01690039|
Recruitment Status : Completed
First Posted : September 21, 2012
Last Update Posted : October 9, 2018
- To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.
- To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.
|Condition or disease||Intervention/treatment|
|Acidosis, Renal Tubular Nephrolithiasis Vacuolar Proton-Translocating ATPases||Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)|
|Study Type :||Observational|
|Actual Enrollment :||170 participants|
|Official Title:||Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers|
|Study Start Date :||September 2012|
|Actual Primary Completion Date :||December 31, 2016|
|Actual Study Completion Date :||May 12, 2017|
All study participants
Furosemide-Fludrocortisone-Test and Ammonium chloride-Loading Test will be performed in renal stone patients.
Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.
Other Name: Application of Furosemide (Lasix® ) and Fludrocortisone (Florinef®)
- Capability of urinary acidification [ Time Frame: Five to six hours ]
- Polymorphisms in the ATP6V1 gene [ Time Frame: 12 months ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01690039
|Department of Nephrology and Hypertension, Bern University Hospital|
|Bern, Switzerland, 3010|
|Principal Investigator:||Daniel Fuster, Attending physician Nephrology||Department of Nephrology and Hypertension, Bern University Hospital|