Vasodilatory and Metabolic Effects of Glucagon-like Peptide-1 in Periphery Circulation in Patients With and Without Type 2 Diabetes Mellitus
|ClinicalTrials.gov Identifier: NCT01689051|
Recruitment Status : Completed
First Posted : September 20, 2012
Last Update Posted : January 31, 2014
Diabetes and high blood pressure are risk factors for developing heart disease. An increase in the number of diabetes patients is expected. This increases the number of patients with heart disease, and since the vast majority with diabetes die from heart disease, it is extremely important to investigate how these diseases can be prevented and treated.
Studies in animals have shown that intestinal hormone glucagon-like peptide-1 (GLP-1) can expand blood vessels, thus lowering blood pressure, but it is not known whether the effects is found in humans, which we will investigate.
Studies have also shown that GLP-1 lowers blood sugar, but it is unclear whether this is solely due to increased insulin production, weight loss associated with GLP-1 intake or GLP-1 has an effect on the muscles which increases the uptake of sugar. We investigate whether GLP-1 enhances the absorption of sugar in the leg.
The investigators also examines whether these effects are greater in people with diabetes then in healthy.
|Condition or disease||Intervention/treatment||Phase|
|Type 2 Diabetes Blod Pressure Glucagon-like Peptide-1 Human Physiology Blood Flow||Other: human glucagon-like peptide 1 (7-36)amide Other: human glucagon-like peptide 1 (9-36)amide||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Study Start Date :||March 2012|
|Actual Primary Completion Date :||April 2013|
|Actual Study Completion Date :||April 2013|
|Active Comparator: Healthy subjects||Other: human glucagon-like peptide 1 (7-36)amide Other: human glucagon-like peptide 1 (9-36)amide|
|Active Comparator: Patients with type 2 diabetes||Other: human glucagon-like peptide 1 (7-36)amide Other: human glucagon-like peptide 1 (9-36)amide|
- Femoral artery blood flow
- Leg glucose uptake
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01689051
|Gentofte Hospital, Department of Cardiology|
|Hellerup, Denmark, 2900|
|Principal Investigator:||Jacob C Sivertsen, MD||University Hospital, Gentofte, Copenhagen|