Social Cognition and Turner Syndrome (COGNITUR)
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|ClinicalTrials.gov Identifier: NCT01687842|
Recruitment Status : Completed
First Posted : September 19, 2012
Last Update Posted : July 25, 2017
Monocentric multidisciplinary study (psychologists, endocrinologists, psychiatrists, and molecular biologists) to characterize social cognition in adolescents with Turner syndrome (TS).
- Turner syndrome with homogeneous 45,X karyotype.
- Age between 8 and 18 years.
- Somatic state compatible with the evaluation.
- Functional language and IQ ≥ 80 for the transfer tests
- Informed consent signed by the holders of parental authority, the patient and the mother for her own participation (DNA collection).
- Affiliation to Social Security (beneficiary or assignee).
The primary endpoint will be the overall score to the AQ (Autism Quotient) questionnaire and to the SRS (Social Reciprocity Scale), in comparison to the expected scores for the general population. For patients with scores above the threshold for SRS or QA validation of a possible diagnosis of autism spectrum disorders will be performed with commonly used diagnostic tools (ADIR (Lord et al, 1994), ADOS-G (Lord et al, 1999) and diagnostic criteria of DSM IV-TR).
Secondary criteria will include the results of standardized tests to assess autistic features (AQ, ADI-R, ADOS, DSM IV-TR criteria), intellectual efficiency (Wechsler scales), psychiatric comorbidities (Kiddie-SADS) and sociocognitive profile (SpeX test, Social cognition, Perception, eXecutive functions).
A DNA sample will be collected from the patient and her mother. The observation period is 2 days for the patient and about 1 hour for the mother. The total duration of the study is 3 years.
|Condition or disease||Intervention/treatment|
|Turner Syndrome||Other: Evaluation of 45,X Turner syndrome patients|
Patients will be recruited to the study by their pediatric endocrinologist during routine monitoring visits. They will then be contacted by phone or by mail for an appointment with their mother for more oral and written information consisting of an information notice and informed consent form. The recruitment of Turner syndrome patients will be based on the Reference Centre for Rare Endocrine Growth Disorders (AP-HP, Robert Debré, Armand Trousseau and Necker hospitals).
The parental origin of the remaining X chromosome will be analyzed using microsatellite analysis and comparison of the profile of the patient and her mother.
Statistical analysis will be conducted under the supervision of Professor C. ALBERTI using commonly accepted standards. All tests will be bilateral. Given the exploratory nature of the study, a significance threshold of 10% will be used. Statistical analyzes will be performed using SAS software V 9.2.
|Study Type :||Observational|
|Actual Enrollment :||25 participants|
|Official Title:||Social Cognition and Turner Syndrome|
|Actual Study Start Date :||March 2013|
|Actual Primary Completion Date :||March 2017|
|Actual Study Completion Date :||March 2017|
Turner syndrome patients
Evaluation of 45,X Turner syndrome patients
Other: Evaluation of 45,X Turner syndrome patients
Evaluation of 45,X Turner syndrome patients
- Overall score to the AQ (Autism Quotient) questionnaire. [ Time Frame: 2 days ]
- SRS (Social Reciprocity Scale), in comparison to the expected scores for the general population. [ Time Frame: 2 days ]
- Socio-cognitive profile and parent of origin of the intact X chromosome [ Time Frame: 2 days ]
Results of standardized tests to assess autistic features (AQ, ADI-R, ADOS, DSM IV-TR criteria), intellectual efficiency (Wechsler scales), psychiatric comorbidities (Kiddie-SADS) and sociocognitive profile (SpeX test, Social cognition, Perception, eXecutive functions).
Parent of origin of the intact X chromosome and its relationship to the autistic features.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01687842
|Robert Debre Hospital|
|Paris, France, 75019|
|Principal Investigator:||Jean-Claude Carel, PHD||Assistance Publique - Hôpitaux de Paris|