Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery. Recently, internal limiting membrane (ILM) peeling has become used widely as an adjunctive procedure during MH surgery because the removal of ILM is thought to reduce the tangential traction on the macula, a major factor in the pathogenesis of idiopathic macular holes. However, the role of ILM peeling in macular hole surgery is not yet well defined. To the best of our knowledge, there is no meta-analysis on comparison of the efficacy of ILM peeling and suture for MH surgery. This study reviewed the published literature comparing surgical results with and without ILM peeling and and performed a meta-analysis to determine whether there is any benefit or detriment anatomically and/or visually.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis|
- Anatomic Success rate [ Time Frame: 12 months ] [ Designated as safety issue: No ]Anatomic success defined as a closed hole without a visible edge or a flat hole without a rim of subretinal fluid.
- Functional Success Rate [ Time Frame: 12 month ] [ Designated as safety issue: No ]Functional Success defined as an improvement of 2 or more Snellen BCVA.
- Best-corrected visual acuity [ Time Frame: 12 month ] [ Designated as safety issue: No ]All Snellen BCVA were converted to logarithm of the minimum angle of resolution (logMAR) BCVA
- Complications [ Time Frame: 12 months ] [ Designated as safety issue: No ]Such as elevated intraocular pressure,retinal tear,rhegmatogenous retinal detachment
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||May 2014|
|Estimated Primary Completion Date:||April 2014 (Final data collection date for primary outcome measure)|
patients were scheduled to undergo macular hole surgery without internal limiting membrane (ILM) peeling
patients were scheduled to undergo macular hole surgery with internal limiting membrane (ILM) peeling
Please refer to this study by its ClinicalTrials.gov identifier: NCT01687829
|Wenzhou Medical College||Recruiting|
|Wenzhou, Zhejiang, China, 325000|
|Contact: Yifan Feng, MD +86-577-88068880 firstname.lastname@example.org|
|Principal Investigator: Yifan Feng, MD|
|Principal Investigator:||Yifan Feng, MD||Wenzhou Medical University|