Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study
|ClinicalTrials.gov Identifier: NCT01687686|
Recruitment Status : Unknown
Verified September 2012 by Owen Nicholas, University College, London.
Recruitment status was: Active, not recruiting
First Posted : September 19, 2012
Last Update Posted : September 19, 2012
|Condition or disease|
|Stable Angina Unstable Angina Non ST Elevation Myocardial Infarction ST Elevation Myocardial Infarction Myocardial Infarction Not Otherwise Specified|
The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.
With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.
|Study Type :||Observational|
|Actual Enrollment :||175872 participants|
|Official Title:||Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)|
|Study Start Date :||January 2001|
|Primary Completion Date :||March 2010|
|Estimated Study Completion Date :||December 2012|
Initially healthy patients in General Practise Research Database (GPRD) meeting the inclusion criteria at any point between 1st January 2001 and 25th March 2010
- Rate of stable angina [ Time Frame: Cohort followed up for average of 7 years ]Incidence of stable angina in study population
- Rate of unstable angina [ Time Frame: Cohort followed up for average of 7 years ]Incidence of unstable angina in study population
- Rate of non ST elevation myocardial infarction [ Time Frame: Cohort followed up for average of 7 years ]Incidence of non ST elevation myocardial infarction
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01687686
|University College London|
|London, Greater London, United Kingdom, WC1E 6BT|