Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study
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|ClinicalTrials.gov Identifier: NCT01687686|
Recruitment Status : Unknown
Verified September 2012 by Owen Nicholas, University College, London.
Recruitment status was: Active, not recruiting
First Posted : September 19, 2012
Last Update Posted : September 19, 2012
|Condition or disease|
|Stable Angina Unstable Angina Non ST Elevation Myocardial Infarction ST Elevation Myocardial Infarction Myocardial Infarction Not Otherwise Specified|
The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.
With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.
|Study Type :||Observational|
|Actual Enrollment :||175872 participants|
|Official Title:||Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)|
|Study Start Date :||January 2001|
|Actual Primary Completion Date :||March 2010|
|Estimated Study Completion Date :||December 2012|
Initially healthy patients in General Practise Research Database (GPRD) meeting the inclusion criteria at any point between 1st January 2001 and 25th March 2010
- Rate of stable angina [ Time Frame: Cohort followed up for average of 7 years ]Incidence of stable angina in study population
- Rate of unstable angina [ Time Frame: Cohort followed up for average of 7 years ]Incidence of unstable angina in study population
- Rate of non ST elevation myocardial infarction [ Time Frame: Cohort followed up for average of 7 years ]Incidence of non ST elevation myocardial infarction
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01687686
|University College London|
|London, Greater London, United Kingdom, WC1E 6BT|