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Diagnostic and Prognostic Value of Combination Biomarkers in the Critically Ill Patient With Sepsis.

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ClinicalTrials.gov Identifier: NCT01687010
Recruitment Status : Unknown
Verified August 2012 by Jianfeng Xie, Southeast University, China.
Recruitment status was:  Recruiting
First Posted : September 18, 2012
Last Update Posted : September 18, 2012
Southeast University, China
Information provided by (Responsible Party):
Jianfeng Xie, Southeast University, China

Brief Summary:
Sepsis is a common cause for morbidity and mortality in critically ill patients. With the development of medical skills, the mortality is still remain very high. Inappropriateness of initial antibiotic treatment is an important risk factor for mortality and effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock. However, the early treatment based on early diagnosis.But it is very difficult to diagnosis because of lack of specific clinic symptom and sign.When severe sepsis occur, biomarker could be helpful to diagnosis. Unfortunately, the diagnostic value of single biomarker is limited. Therefore, combine several biomarkers could enhance the diagnostic value.

Condition or disease
Diagnostic and Predictive Value

Study Type : Observational
Estimated Enrollment : 300 participants
Time Perspective: Prospective
Study Start Date : March 2012
Estimated Study Completion Date : October 2012

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Critically ill patients

Inclusion Criteria:

  • Critically ill patients admitted into ICU

Exclusion Criteria:

  • Age younger than 18 years
  • Refuse to participate in this study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01687010

Contact: Jianfeng Xie, M.D. +8602583272201 seuicu@yahoo.com.cn

China, Jiangsu
Department of Critical Care Medicine Nanjing Zhong-da Hospital Southeast University School of Medicine Recruiting
Nanjing, Jiangsu, China, 210009
Contact: Yi Yang, M.D., Ph.D,    +8602583272202    yiyiyang2004@yahoo.com.cn   
Sponsors and Collaborators
Jianfeng Xie
Southeast University, China

Responsible Party: Jianfeng Xie, Physician of critical care department, Southeast University, China
ClinicalTrials.gov Identifier: NCT01687010     History of Changes
Other Study ID Numbers: PCT001
First Posted: September 18, 2012    Key Record Dates
Last Update Posted: September 18, 2012
Last Verified: August 2012

Keywords provided by Jianfeng Xie, Southeast University, China:
CRP, PCT, IL-6, Diagnosis, Prediction