Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.
The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease|
- Carbon dioxide elimination in a ventilator assisted breath. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]
- Blood CO2 concentration. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]
|Study Start Date:||September 2012|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
Experimental: Altered breath
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
|Other: Altered breath|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01686984
|Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund|
|Lund, Skane, Sweden, 22185|
|Principal Investigator:||Mikael Bodelsson, Professor||Division of Anesthesia, Skane University Hospital, Lund, Sweden|