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Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

This study has been completed.
Information provided by (Responsible Party):
Region Skane Identifier:
First received: September 13, 2012
Last updated: May 13, 2015
Last verified: May 2015

The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.

Condition Intervention
Pulmonary Gas Exchange
Carbon Dioxide
Other: Altered breath

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

Resource links provided by NLM:

Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Carbon dioxide elimination in a ventilator assisted breath. [ Time Frame: 30 minutes ]

Secondary Outcome Measures:
  • Blood CO2 concentration. [ Time Frame: 30 minutes ]

Enrollment: 8
Study Start Date: September 2012
Study Completion Date: May 2015
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Altered breath
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Other: Altered breath


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • No known primary lung disease

Exclusion Criteria:

  • Primary lung disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01686984

Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund
Lund, Skane, Sweden, 22185
Sponsors and Collaborators
Region Skane
Principal Investigator: Mikael Bodelsson, Professor Division of Anesthesia, Skane University Hospital, Lund, Sweden
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Region Skane Identifier: NCT01686984     History of Changes
Other Study ID Numbers: 2012/381
Study First Received: September 13, 2012
Last Updated: May 13, 2015

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases processed this record on May 23, 2017