Endothelin-1 and Methabolites Concentrations in Mycrodialysis and Cerebrospinal Fluid in Subarachnoid Hemorrhage Patients
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|ClinicalTrials.gov Identifier: NCT01686763|
Recruitment Status : Completed
First Posted : September 18, 2012
Last Update Posted : March 18, 2013
Endothelin-1 (ET-1) seems to be involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. However measurements of cerebrospinal fluid concentrations (CSF) of ET-1 are not sensitive enough to predict the development of vasospasm representing the average value throughout the entire cerebral circulation. Cerebral microdialysis (MD) is a technique able to detect molecule concentrations in a small perivascular area. The investigators performed a prospective observational clinical study to test the hypothesis that MD ET-1 concentrations should be a sensitive predictor for vasospasm.
Patients with subarachnoid hemorrhage at high risk for vasospasm according to Fisher scale admitted to the ICU were consecutively studied. All patients received surgery within 48 hours from the bleeding; MD probe was placed in the area at risk for vasospasm after surgery and samples were hourly collected and analysed to measure lactate, piruvate and glutamate levels; ET-1 levels in CSF and MD fluids were measured from admission until day 7. At admission and after 7 days two angiographies were performed to detect the degree and extent of vasospasm, Transcranial Doppler and neurological evaluation were daily performed. Patients were then classified according to the presence of vasospasm in 3 groups: absence of vasospasm (NV), presence of vasospasm (CV), acute neurological deterioration (AND).
|Condition or disease|
|Subarachnoid Hemorrhage, Aneurysmal|
|Study Type :||Observational|
|Actual Enrollment :||35 participants|
|Study Start Date :||January 2004|
|Actual Primary Completion Date :||December 2008|
subarachnoid hemorrhage disease
subarachnoid hemorrhage patients
- cerebral vasospasm incidence [ Time Frame: 14 days ]
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01686763
|Principal Investigator:||Luciana Mascia, MD, PhD||University of Turin, Italy|