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Free Fatty Acids: Short Exposure Study

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ClinicalTrials.gov Identifier: NCT01686113
Recruitment Status : Completed
First Posted : September 17, 2012
Last Update Posted : November 21, 2014
Sponsor:
Information provided by (Responsible Party):
Richard Mattes, Purdue University

Study Description
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Brief Summary:
This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.

Condition or disease Intervention/treatment Phase
Hypogeusia Other: NEFA Other: Sucrose Not Applicable

Detailed Description:
The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste - is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Free Fatty Acids: Short Exposure Study
Study Start Date : May 2012
Actual Primary Completion Date : May 2014
Actual Study Completion Date : May 2014
Arms and Interventions
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Arm Intervention/treatment
Experimental: NEFA
Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.
 Other: NEFA
Other Name: Oleic acid
Active Comparator: Control
Participants swish and spit 5 mL of sucrose solution everyday for 10 days.
 Other: Sucrose


Outcome Measures
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Primary Outcome Measures :
  1. NEFA detection threshold [ Time Frame: 10 days ]

Secondary Outcome Measures :
  1. Hunger [ Time Frame: 2 days ]
    Visual analog scale assessment of hunger level prior to testing

  2. BMI [ Time Frame: 1 day ]
  3. Taste descriptor [ Time Frame: 10 days ]
    Description of NEFA taste by participant, e.g., sour, bitter, etc.


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • good health
  • available for multiple testing visits

Exclusion Criteria:

  • have participated in a fat taste study in the past 6 months
Contacts and Locations
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01686113


Locations
United States, Indiana
Purdue University
West Lafayette, Indiana, United States, 47907
Sponsors and Collaborators
Purdue University
Investigators
Principal Investigator: Richard D Mattes, PhD Purdue University
More Information
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Richard Mattes, Distinguished Prof Foods and Nutrition, Purdue University
ClinicalTrials.gov Identifier: NCT01686113     History of Changes
Other Study ID Numbers: 1205012317
First Posted: September 17, 2012    Key Record Dates
Last Update Posted: November 21, 2014
Last Verified: November 2014

Keywords provided by Richard Mattes, Purdue University:
Taste
Fat Taste
Threshold Testing

Additional relevant MeSH terms:
Ageusia
Taste Disorders
Sensation Disorders
 Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms