Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving
Recruitment status was: Recruiting
Specific Primary Aims include:
Aim # 1. The investigators explore the feasibility of using the TMS to investigate the cortical excitability and to inhibit meth cue craving in meth dependent population. The investigators anticipate that meth elevates cortical excitability measured by motor threshold, causes changes of cortical silent period, and RC. The investigators also anticipate that paired pulse measures (short-interval intracortical inhibition, short-interval intracortical facilitation and long-interval intracortical inhibition) will be different from healthy control, which are more directly linked to glutamatergic cortical facilitation and GABAergic inhibition, respectively.
Aim # 2. Given the change of the cortical excitability in meth users, the investigators will use inhibiting TMS (1 Hz) over medial prefrontal cortex to study whether TMS can be used to reduce cue craving. The investigators hypothesize that repetitive TMS reduce meth cue craving in meth dependent population compared with sham rTMS.
|Methamphetamine Dependence||Device: Transcranial Magnetic Stimulation Device: Sham Transcranial Magnetic Stimulation||Early Phase 1|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment
|Official Title:||Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving|
- Cue craving rating [ Time Frame: Change from Baseline in Craving rating 10 minutes after TMS ]The subject is asked to rate craving with 0 mm being " no craving at all" and 100 mm representing "the most craving I have ever had".
- cortical excitability [ Time Frame: Change from Baseline in cortical excitability 10 minutes after TMS ]
Cortical Excitability Include:
Resting motor threshold (RMT); Cortical silent period (CSP); Recruitment curve (RC); Paired-pulse (PP)
|Study Start Date:||September 2008|
|Estimated Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Experimental: Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technology that can focally stimulate the brain of an awake individual. The brain stimulation techniques could theoretically improve the efficacy of smoking cessation.
Device: Transcranial Magnetic Stimulation
Active TMS:1 Hz, 100% motor threshold TMS for 15 minutes, total 900 pulses. Electrical stimulation instead.
Other Name: Magstim Rapid
Placebo Comparator: Sham Transcranial Magnetic Stimulation
Sham-TMS procedures: After rTMS determination, participants were fitted with two electrodes on the scalp just below the hairline. Electrodes will be connected to an Epix VT Transcutaneous Electrical nerve stimulation device.
Device: Sham Transcranial Magnetic Stimulation
The electrical current of the sham system is titrated to a level matching participants' ratings of active TMS. The sham-TMS scalp discomfort will be matched to that of active TMS.
Other Name: Epix VT Transcutaneous Electrical Nerve Stimulation Device
Please refer to this study by its ClinicalTrials.gov identifier: NCT01685463
|United States, South Carolina|
|Medical University of South Carolina||Recruiting|
|Charleston, South Carolina, United States, 29425|
|Contact: Xingbao Li, M.D 843-792-5729 firstname.lastname@example.org|
|Contact: Kristina Huebner 843 7921901 email@example.com|
|Principal Investigator: Ronald E See, Ph.D|
|Sub-Investigator: Xingbao Li, M.D|