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Intensive Dysarthria Sessions in Adults and Children With Down Syndrome

This study has been completed.
University of Rhode Island
University of Florida
University of North Carolina, Chapel Hill
Information provided by (Responsible Party):
Duke University Identifier:
First received: September 11, 2012
Last updated: November 22, 2016
Last verified: November 2016
This research study is designed to investigate the feasibility and treatment effects of a behavioral speech treatment in adults and children with Down Syndrome (DS) and dysarthria. The speech sessions will provide an intensive, articulation-based intervention focused on increasing effort during speech production via use of "clear speech." A single subject multiple baselines across subjects design will be employed in a total of six subjects divided into two groups of three. Changes in dependent measures will be determined by visual inspection, effect size determination, and time series analysis. The study follows accepted procedures in rehabilitation treatment and research and there are minimal foreseeable risks associated with participation.

Condition Intervention
Down Syndrome
Behavioral: Speech sessions

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Intensive Dysarthria Sessions in Adults and Children With Down Syndrome

Resource links provided by NLM:

Further study details as provided by Duke University:

Primary Outcome Measures:
  • Speech intelligibility [ Time Frame: 3-6 months ]
    Speech intelligibility in sentences scored by naive listeners.

Enrollment: 5
Study Start Date: February 2014
Study Completion Date: May 2016
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Behavioral speech treatment Behavioral: Speech sessions
Subjects will be instructed to use clear speech and increased effort when speaking.


Ages Eligible for Study:   8 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adults and children with Downs Syndrome and dysarthria
  • Ages 8 years and older
  • Ability to verbally communicate; follow simple commands and/or imitate others; hear speech at a conversational level; and participate in assessment and speech sessions activities

Exclusion Criteria:

  • Additional serious medical problems which prevent meaningful participation in the study.
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Please refer to this study by its identifier: NCT01684670

United States, North Carolina
Duke University Health System
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
University of Rhode Island
University of Florida
University of North Carolina, Chapel Hill
Principal Investigator: Harrison N Jones, PhD Duke University
  More Information

Responsible Party: Duke University Identifier: NCT01684670     History of Changes
Other Study ID Numbers: Pro00039730
Study First Received: September 11, 2012
Last Updated: November 22, 2016

Additional relevant MeSH terms:
Down Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Articulation Disorders
Speech Disorders
Language Disorders
Communication Disorders
Signs and Symptoms processed this record on May 25, 2017