Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by Hillel Yaffe Medical Center.
Recruitment status was  Not yet recruiting
Information provided by (Responsible Party):
Hillel Yaffe Medical Center Identifier:
First received: September 5, 2012
Last updated: September 10, 2012
Last verified: September 2012

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.

Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.

Condition Intervention
Other: Respiratory secretions obtained

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • Number of Immature Myeloid Cells in Respiratory Secretions [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of one week ] [ Designated as safety issue: No ]
    Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells

Estimated Enrollment: 55
Study Start Date: October 2012
Estimated Study Completion Date: January 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Children Suffering From Bronchiolitis
Respiratory secretions obtained from children suffering from Bronchiolitis
Other: Respiratory secretions obtained
Healthy Children
Respiratory secretions obtained from children with no respiratory infection
Other: Respiratory secretions obtained


Ages Eligible for Study:   up to 2 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Children presenting in our pediatric department suffering from bronchiolitis


Inclusion Criteria:

  • Bronchiolitis

Exclusion Criteria:

  • Chronic disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01684527

Hillel Yaffe Medical Center Not yet recruiting
Hadera, Israel, 38100
Contact: Vered Nir, MD    972-4-630-4331   
Principal Investigator: Vered Nir, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
  More Information

No publications provided

Responsible Party: Hillel Yaffe Medical Center Identifier: NCT01684527     History of Changes
Other Study ID Numbers: 0039-12-HYMC
Study First Received: September 5, 2012
Last Updated: September 10, 2012
Health Authority: Israel: Ministry of Health processed this record on February 27, 2015