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Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

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ClinicalTrials.gov Identifier: NCT01684527
Recruitment Status : Unknown
Verified September 2012 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : September 13, 2012
Last Update Posted : September 13, 2012
Information provided by (Responsible Party):

Study Description
Brief Summary:

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.

Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.

Condition or disease Intervention/treatment
Bronchiolitis Other: Respiratory secretions obtained

Study Design

Study Type : Observational
Estimated Enrollment : 55 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : October 2012
Estimated Primary Completion Date : January 2014
Estimated Study Completion Date : January 2014
Groups and Cohorts

Group/Cohort Intervention/treatment
Children Suffering From Bronchiolitis
Respiratory secretions obtained from children suffering from Bronchiolitis
Other: Respiratory secretions obtained
Healthy Children
Respiratory secretions obtained from children with no respiratory infection
Other: Respiratory secretions obtained

Outcome Measures

Primary Outcome Measures :
  1. Number of Immature Myeloid Cells in Respiratory Secretions [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of one week ]
    Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 2 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Children presenting in our pediatric department suffering from bronchiolitis

Inclusion Criteria:

  • Bronchiolitis

Exclusion Criteria:

  • Chronic disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01684527

Hillel Yaffe Medical Center Not yet recruiting
Hadera, Israel, 38100
Contact: Vered Nir, MD    972-4-630-4331    verednr@yahoo.com   
Principal Investigator: Vered Nir, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
More Information

Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01684527     History of Changes
Other Study ID Numbers: 0039-12-HYMC
First Posted: September 13, 2012    Key Record Dates
Last Update Posted: September 13, 2012
Last Verified: September 2012

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Infections