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Pulmonary Rehabilitation Before Lung Cancer Resection

This study is enrolling participants by invitation only.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Roberto P. Benzo, Mayo Clinic Identifier:
First received: September 4, 2012
Last updated: March 17, 2016
Last verified: January 2016
This study seeks to study the effectiveness of a short mindfulness based pulmonary rehabilitation program prior to a surgical resection in patients with lung cancer and severe Chronic Obstructive Lung Disease (COPD).

Condition Intervention
Lung Cancer
Chronic Obstructive Lung Disease
Behavioral: Mindfulness Based Pulmonary Rehabilitation
Other: Usual Care

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Supportive Care
Official Title: Pulmonary Rehabilitation Before Lung Cancer Resection

Resource links provided by NLM:

Further study details as provided by Roberto P. Benzo, Mayo Clinic:

Primary Outcome Measures:
  • Measure of length of hospital stay post surgical resection of lung cancer in patients that underwent a resection for lung cancer. [ Time Frame: baseline to release from hospital - approx 10 days ]
    The length of hospital stay will be compared between participants that under went 10 Mindful Rehabilitation Sessions with participants who received the usual care prior to a lung resection.

Secondary Outcome Measures:
  • Measure post-operative complications in patients that under went 10 session of Mindful Pulmonary Rehabilitation prior to lung resection compared to patients who received usual care prior to a lung resection for lung cancer. [ Time Frame: Post surgerybaseline to release from hospital - approx 10 days ]
    The study will compare the number of ICU days, ventilation hours, number of days with a chest tube, subsequent pneumonia or respiratory failure in patients that underwent 10 Mindful Pulmonary Rehabilitation sessions prior to a lung resection to patients who received the usual care prior to a lung resection for lung cancer.

Estimated Enrollment: 154
Study Start Date: August 2013
Estimated Study Completion Date: October 2016
Estimated Primary Completion Date: August 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Intervention
The Intervention Arm will receive 10 sessions of Mindfulness Based Pulmonary Rehabilitation prior to lung surgery
Behavioral: Mindfulness Based Pulmonary Rehabilitation
Participants in this group will under go 10 sessions of mindfulness based pulmonary rehabilitation prior to surgery. Each session is about 2 hours long and consists of upper /lower extremity training, breathing exercises, and education.
Placebo Comparator: Usual Care
The Usual Care Arm will receive the normal care that a patient with severe COPD having a lung surgery would receive.
Other: Usual Care


Ages Eligible for Study:   40 Years to 100 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patient is scheduled to undergo a surgery for non small cell lung cancer
  • Moderate to severe COPD
  • Current or ex smoker of ten or more years

Exclusion Criteria:

  • Unable to perform exercise due to active cardiovascular, musculoskeletal or mental problems Poorly motivated to attend the rehabilitation sessions or receive randomization.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01682850

United States, Florida
Mayo Clinic
Jacksonville, Florida, United States, 32224
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Washington University
St Louis, Minnesota, United States, 63110
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15232
United States, Virginia
University of Virginia
Charlottesville, Virginia, United States, 22908
Sponsors and Collaborators
Mayo Clinic
National Cancer Institute (NCI)
Principal Investigator: Roberto P Benzo, MD Mayo Clinic
  More Information

Responsible Party: Roberto P. Benzo, Principle Investigator, Mayo Clinic Identifier: NCT01682850     History of Changes
Other Study ID Numbers: 11-005820
1R01CA163293-01 ( US NIH Grant/Contract Award Number )
Study First Received: September 4, 2012
Last Updated: March 17, 2016

Keywords provided by Roberto P. Benzo, Mayo Clinic:
Chronic Obstructive Lung Disease
lung cancer
Pulmonary Rehabilitation

Additional relevant MeSH terms:
Lung Neoplasms
Lung Diseases
Pulmonary Emphysema
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Respiratory Tract Diseases
Pathologic Processes processed this record on May 25, 2017