Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children
In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults.
The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children|
- genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis [ Time Frame: Oct 2013 ~ Dec 2014 ]
- genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance [ Time Frame: Oct 2013 ~ Dec 2014 ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||July 2012|
|Study Completion Date:||December 2014|
|Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. In addition, the investigators will further analyze the association with other biomarkers, such as body mass index, adiponectin and insulin resistance.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01682655
|Far Eastern Memorial Hospital|
|New Taipei City, Taiwan, 220|
|Principal Investigator:||Yu-Cheng Lin, MD, PhD||Far Eastern Memorial Hospital|