Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

A Prospective Trial of Ultrasound Versus Landmark Guided Central Venous Access in the Pediatric Population

This study has been completed.
Information provided by (Responsible Party):
Matias Bruzoni, Stanford University Identifier:
First received: August 28, 2012
Last updated: January 26, 2015
Last verified: January 2015
The investigators hypothesized that, in children undergoing venous cannulation for central line placement by pediatric surgeons, ultrasound-guided cannulation leads to an increase in successful venous cannulation at first attempt compared to landmark guided cannulation.

Condition Intervention
Need for Central Venous Access
Procedure: central line placement
Device: Ultrasound

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Prospective Randomized Trial of Ultrasound Versus Landmark Guided Central Venous Access in Children

Resource links provided by NLM:

Further study details as provided by Matias Bruzoni, Stanford University:

Primary Outcome Measures:
  • Success of Central Venous Cannulation at First Attempt. [ Time Frame: April 2008-September 2011 ]

Secondary Outcome Measures:
  • Total Number of Venous Cannulation Attempts [ Time Frame: April 2008-September 2011 ]
  • Number of Arterial Punctures [ Time Frame: April 2008-September 2011 ]
  • Number of Complications [ Time Frame: April 2008-September 2011 ]

Enrollment: 150
Study Start Date: May 2009
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: landmark guided
central line placement
Procedure: central line placement
central line placement
Active Comparator: ultrasound guided
central line placement
Procedure: central line placement
central line placement
Device: Ultrasound
Ultrasound guided central venous access
Other Names:
  • Sonosite, Bothel, WA
  • Aloka, Wallingford, CT


Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All patients between the ages of 0 and 18 years undergoing tunneled central venous line placement under general anesthesia

Exclusion Criteria:

  • Preoperative proof of non-patency of central veins
  • coagulopathy
  • access site surgeon
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01680666

United States, California
Stanford University
Palo Alto, California, United States, 94304
United States, Missouri
Children's Mercy Hospital
Kansas City, Missouri, United States
Sponsors and Collaborators
Stanford University
  More Information

Responsible Party: Matias Bruzoni, Principle Investigator, Stanford University Identifier: NCT01680666     History of Changes
Other Study ID Numbers: IRB-8943
Study First Received: August 28, 2012
Results First Received: January 26, 2015
Last Updated: January 26, 2015 processed this record on May 25, 2017