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Calorie Anticipation and Food Intake

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ClinicalTrials.gov Identifier: NCT01680315
Recruitment Status : Completed
First Posted : September 7, 2012
Last Update Posted : September 7, 2012
Sponsor:
Information provided by (Responsible Party):
Uppsala University

Brief Summary:

The regulation of our food intake is on the short-term guided by appetite and satiety signals generated by the sight and consumption of food. Food intake is not only regulated by appetite and satiety signals - external cues also play an important role.

It has been observed that food intake and the pleasure derived from consumption is affected by manipulation of the external cues.

The investigators will assess the contribution of food anticipation (calorie information) and actual consumption of a test food (calorie intake) on in satiety responses (such as ghrelin responses, appetite and subsequent food intake). The investigators expect the information on the amount of calories, rather than the actual amount of calories in the food, to predict the ghrelin responses and the subsequent intake of a second meal.


Condition or disease Intervention/treatment Phase
Eating Behaviour Obesity Behavioral: low calorie yogurt Behavioral: high calorie yogurt Not Applicable

Detailed Description:
In a randomized cross-over design with 4 conditions, all participants will consume twice the low-caloric food (once with the low-calorie information and once with the high-calorie information) and twice the high-caloric food (again, once with the low-calorie information and once with the high-calorie information) in a randomized order.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Differences in Physiological Responses of Satiety and Reward After (in)Consistent Calorie Cues.
Study Start Date : May 2012
Actual Primary Completion Date : July 2012
Actual Study Completion Date : August 2012

Arm Intervention/treatment
Experimental: Calorie information

Low calorie yogurt

High calorie yogurt

with low calorie information sheet

Behavioral: low calorie yogurt
all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)
Behavioral: high calorie yogurt
all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)
Experimental: Calorie information (high)

Low calorie yogurt

High calorie yogurt

High calorie information sheet

Behavioral: low calorie yogurt
all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)
Behavioral: high calorie yogurt
all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)



Primary Outcome Measures :
  1. Food intake [ Time Frame: 60 min (Ad libitum test meal after 1 hr) ]

Secondary Outcome Measures :
  1. Serum concentrations total ghrelin [ Time Frame: 60 min (4 samples - every 20 min) ]

Other Outcome Measures:
  1. appetite ratings [ Time Frame: 80 min (5 samples - every 20 min) ]
  2. Serum cortisol concentrations [ Time Frame: 60 min (4 samples - every 20 min) ]


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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • female
  • healthy
  • being used to eat breakfast regularly (≥ 5 times a week).

Exclusion Criteria:

  • hypersensitivity for the ingredients of the foods under study;
  • lack of appetite; following an energy-restricted diet or change in body weight > 5 kg; or
  • being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01680315


Locations
Sweden
Uppsala University
Uppsala, Sweden, 75319
Sponsors and Collaborators
Uppsala University
Investigators
Principal Investigator: Pleunie Hogenkamp, PhD Uppsala University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Uppsala University
ClinicalTrials.gov Identifier: NCT01680315     History of Changes
Other Study ID Numbers: PH2012
First Posted: September 7, 2012    Key Record Dates
Last Update Posted: September 7, 2012
Last Verified: August 2012

Keywords provided by Uppsala University:
Satiety,
satiation,
anticipation,
food intake