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Evaluation of Brain MRI and Clinical Characteristics of Adolescents With Bipolar Disorder and Children of Parents With Bipolar Disorder

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ClinicalTrials.gov Identifier: NCT01678989
Recruitment Status : Unknown
Verified August 2012 by Seher Akbas, Turkish Psychiatry Association.
Recruitment status was:  Recruiting
First Posted : September 5, 2012
Last Update Posted : September 5, 2012
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Genetic transition is important in the etiology of bipolar disorder (BD). So, evaluation of children of BD parents and diagnosed with and BD children whether or not brain has affected zones. These groups were compared to healthy controls and whether or not the mental health of children is influenced will be evaluated by the clinical investigation.

Condition or disease
Bipolar Disorder

Detailed Description:
MRI studies in children at risk of BD, our understanding of the neurobiology of BD and abnormalities in the studied regions, regions that predispose to the development of our understanding of PBB will shed light on the etiology of the disorder. In this study, the cranial MRI findings and clinical features in adolescents with bipolar disorder and the same age and sex matched children who have parents with BD and healthy controls were investigated. Since there is few studies that evaluate these three groups, there is a need to increase our knowledge on this issue.

Study Design

Study Type : Observational
Estimated Enrollment : 60 participants
Time Perspective: Prospective
Study Start Date : July 2011
Estimated Primary Completion Date : June 2013
Estimated Study Completion Date : June 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bipolar Disorder
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
Patient group
Children with BD, (20 children) 12-18 year-old who agreed to participate in the study will be established.
Risk group
Twenty healthy children of 12-18 years old who have mothers and/or fathers who previously assessed by an adult psychiatrist and diagnosed as BD according to DSM-IV diagnostic criteria, and who agreed to participate in the study. The age and gender of the groups will be matched.
Healthy control group
Twenty participants between the ages of 12-18 who agree to participate in the study and whose family members do not have BD. The age and the gender of the groups will be matched.


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
In this study, the cranial MRI findings and clinical features in adolescents with bipolar disorder and the same age and sex matched children who have parents with BD and healthy controls were investigated.
Criteria

Inclusion Criteria:

  • Children with BD between the ages of 12-18
  • Parents with BD who have children between the ages of 12-18
  • Healthy children whose parents do not have BD
  • Patients who does not have mental or organic disability to answer the questions
  • Graduated from primary school

Exclusion Criteria:

  • Patients who have mental or organic disability to answer the questions
  • Patients who have a history of any chronic disease which is likely to affect the central nervous system
  • Patients who have a contraindication for any first application for Magnetic Resonance Imaging (MRI)
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01678989


Contacts
Contact: Seher Akbas 09003623121919 ext 3128 akbasseher@hotmail.com
Contact: Gökhan Sarisoy 09003623121910 ext 3777 gokhansarisoy@gmail.com

Locations
Turkey
Ondokuz Mayis University Medical Faculty Department of Child and Adolescent Psychiatry Recruiting
Samsun, Turkey, 55139
Contact: Seher Akbas    00903623121919 ext 3128    akbasseher@hotmail.com   
Principal Investigator: Seher Akbas         
Sponsors and Collaborators
Turkish Psychiatry Association
More Information

Responsible Party: Seher Akbas, Associate Professor, Turkish Psychiatry Association
ClinicalTrials.gov Identifier: NCT01678989     History of Changes
Other Study ID Numbers: 4946498
First Posted: September 5, 2012    Key Record Dates
Last Update Posted: September 5, 2012
Last Verified: August 2012

Keywords provided by Seher Akbas, Turkish Psychiatry Association:
Bipolar disorder
Children
Cranial MRI

Additional relevant MeSH terms:
Bipolar Disorder
Bipolar and Related Disorders
Mental Disorders