Ventricular Volume as Assessed by Cardiac Magnetic Resonance
|ClinicalTrials.gov Identifier: NCT01678040|
Recruitment Status : Unknown
Verified August 2012 by The Hospital for Sick Children.
Recruitment status was: Active, not recruiting
First Posted : September 3, 2012
Last Update Posted : September 3, 2012
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||15 participants|
|Official Title:||MRI Assessment of the Effect of Preload on Ventricular Volumes and Function in Healthy Adult Volunteers|
|Study Start Date :||May 2012|
|Primary Completion Date :||August 2012|
|Estimated Study Completion Date :||December 2012|
Cardiac Magnetic Resonance
The CMR examinations will be performed in the cardiac MRI scanner (Siemens "Avanto", 1.5 Tesla, Erlangen, Germany) at the Hospital for Sick Children. A brief echocardiogram will be performed using a GE Vivid 7 or Vivid E9 machine (General Electric Medical Systems, Wisconsin, USA) We will image from standard parasternal long axis and apical four-chamber before and after completed hydration.
- Fluid Status [ Time Frame: Day 1 ]To assess ventricular volumes in the fasting state and after oral hydration in order to assess the effect of fluid status on ventricular volumes as measured by CMR.
- Hydration [ Time Frame: Day 1 ]To evaluate the effect of hydration on ventricular volumes compared the effect of with inter-observer and intra-observer variability.
- Chamber Deformation [ Time Frame: Day 1 ]To evaluate the effects of chamber volume on chamber deformation, including strain and peak strain rate
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01678040
|The Hospital for Sick Children|
|Toronto, Ontario, Canada, M5G 1X8|
|Principal Investigator:||Lars Grosse-Wortmann, MD||The Hospital for Sick Children|