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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Participants will be non-smoking males or non-pregnant females aged 20-45y, with normal glycemia and in good health. A total of 12 participants will be included, where approximately half will be male & half female, and half normal weight (BMI > 19.0 and < 25.0) and half overweight but not obese (BMI > 25.0 and < 30). Thus, no fewer than 5 male, 5 female, 5 normal weight and 5 overweight but not obese subjects will be included. Additional inclusion criteria will include:
Absence of diabetes, impaired glucose tolerance and impaired fasting glucose, defined as having a fasting plasma glucose < 5.6 mmol/L (100 mg/dL) AND plasma glucose levels < 7.8 mmol/L (140 mg/dL) 2h after consumption of a 50 g glucose drink (OGTT will be administered during the screening visit)
Systolic blood pressure 100-150 mmHg inclusive
Diastolic blood pressure 60-90 mmHg inclusive
Resting heart rate 50-90 beats/min inclusive after 3 minute rest
Able to refrain from eating legumes and drinking alcohol the day before each test session
Fasting triglycerides < 2.0 mmol/L (178 mg/dL)
Fasting HDL cholesterol > 0.9 mmol/L (35 mg/dL) for males and > 1.1mmol/L (42 mg/dL) for females
Fasting LDL cholesterol < 5.0 mmol/L (193 mg/dL)
AST and ALT < 120% of upper limit of normal (ULN)
hsCRP < 10 mg/L
Urea and creatinine < 150% ULN
failure to meet any one of the inclusion criteria
age less than 18 or over 45 years
known history or AIDS, hepatitis, diabetes or a heart condition
participants using medications or with any condition which might, in the opinion of Dr. Wolever, the president of GI Testing, either: 1) make participation dangerous to the subject or to others, or 2) affect the results
participants who cannot or will not comply with the experimental procedures or do not follow GI Labs safety guidelines.
Food allergies of any kind
General anaesthesia in the month prior to inclusion.