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The Diastolic Pressure Gradient for Patients With Acute Coronary Syndrome: Evaluation of Non Culprit Lesions (FORECAST)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2012 by Ciro Indolfi, University Magna Graecia.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Ciro Indolfi, University Magna Graecia Identifier:
First received: August 20, 2012
Last updated: August 22, 2012
Last verified: August 2012

The assessment of non-culprit stenoses is an important issue in ACS. Adenosine administration is currently required for functional evaluation of stenosis severity using the fractional flow reserve (FFR). An alternative adenosine-independent index of coronary stenosis, the instantaneous wave-free ratio (iFR), was recently introduced.

Aim of the present study will be to evaluate the trans-stenotic instantaneous wave-free pressure gradient (iFG), the instantaneous wave-free ratio (iFR) and the fractional flow reserve (FFR) in ACS patients.

Condition Intervention
Functional Evaluation of Non Culprit Lesions in ACS Patients
Other: Measurement of intracoronary pressure

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Ciro Indolfi, University Magna Graecia:

Groups/Cohorts Assigned Interventions
Acute Coronary Syndrome
Patients with Acute Coronary Syndrome and multivessel coronary artery disease undergoing functional evaluation of non-culprit lesions.
Other: Measurement of intracoronary pressure


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with Acute Coronary Syndrome and multivessel coronary artery disease.

Inclusion Criteria:

  • age 40 to 80 years
  • recent Acute Coronary Syndrome
  • indication for coronary angiography
  • presence of at least one non-culprit lesion requiring functional evaluation with fractional flow reserve (FFR):

Exclusion Criteria:

  • Haemodynamically significant valvular disease
  • controindication for Adenosin administration
  • previous CABG on the index vessel
  Contacts and Locations
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Please refer to this study by its identifier: NCT01671631

Contact: Ciro Indolfi, Prof +3909613647067

Cardiologia Interventistica UMG Recruiting
Catanzaro, Calabria, Italy, 88100
Contact: Ciro Indolfi, Prof.    +3909613647067   
Principal Investigator: Ciro Indolfi, MD         
Sponsors and Collaborators
University Magna Graecia
  More Information

Additional Information:
Responsible Party: Ciro Indolfi, Professor, University Magna Graecia Identifier: NCT01671631     History of Changes
Other Study ID Numbers: FORECAST
Study First Received: August 20, 2012
Last Updated: August 22, 2012 processed this record on May 25, 2017