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The Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients

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ClinicalTrials.gov Identifier: NCT01670903
Recruitment Status : Unknown
Verified August 2012 by Dr. Daniel Silverberg, Sheba Medical Center.
Recruitment status was:  Recruiting
First Posted : August 22, 2012
Last Update Posted : August 22, 2012
Sponsor:
Information provided by (Responsible Party):
Dr. Daniel Silverberg, Sheba Medical Center

Brief Summary:

Abdominal aortic aneurysm (AAA) is a common disease that develops from degeneration of the aortic wall. The natural history of AAA is gradual expansion and if left untreated may result in rupture and death. The mechanism of the development of this disease is unknown however it appears to be multifactorial and possibly related to degradation processes within the arterial wall. There is growing evidence that Angiotensin receptor blockers ( ARBS) may have an inhibitory effect on remodelling processes within the arterial wall, thus inhibiting degeneration of the vessel wall.

Study hypothesis: ARBS are associated with smaller diameters of aortas among hypertensive patients, and are associated with a lower rate of aortic expansion compared to other antihypertensive drugs.


Condition or disease
Aneurysm Hypertension

Study Type : Observational
Estimated Enrollment : 150 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: the Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
Study Start Date : May 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Aneurysms

Group/Cohort
ARBs
Hypertensive patients treated with ARBs
ACE inhibitors
Hypertensive patients treated with ACE inhibitors
non ARB/ACE
Hypertensive patients treated with non ARBs or ACE inhibitors meds




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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
medically treated hypertensive patients, ages 50-80
Criteria

Inclusion Criteria:

  • medically treated hypertensive patients, ages 50-80

Exclusion Criteria:

  • pregnant women
  • patients previously treated for aortic disease
  • unable to sign informed consent, minors

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01670903


Contacts
Contact: Daniel Silverberg, MD 035302712 Daniel.Silverberg@sheba.health.gov.il

Locations
Israel
Sheba Medical Center Recruiting
Tel Hashomer, Israel
Sub-Investigator: Jacob Schneiderman, MD         
Sub-Investigator: Ehud Grossman, MD         
Sub-Investigator: Moshe Halak, MD         
Sub-Investigator: Anan Younes, MD         
Sub-Investigator: Dmitry Yakubovitz, MD         
Sub-Investigator: Bashir Sheik-yosef, MD         
Sub-Investigator: Ronnie E Reinitz, MD         
Sheba Medical Center Recruiting
Tel Hashomer, Israel
Contact: Daniel Silverberg, MD       Daniel.Silverberg@sheba.health.gov.il   
Sponsors and Collaborators
Sheba Medical Center
Investigators
Principal Investigator: Daniel Silverberg, MD Sheba Medical Center

Responsible Party: Dr. Daniel Silverberg, Senior consultant - Vascular surgery, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT01670903     History of Changes
Other Study ID Numbers: SHEBA-12-8336-DS-CTIL
First Posted: August 22, 2012    Key Record Dates
Last Update Posted: August 22, 2012
Last Verified: August 2012

Additional relevant MeSH terms:
Aneurysm
Vascular Diseases
Cardiovascular Diseases
Angiotensin-Converting Enzyme Inhibitors
Angiotensin II
Angiotensinogen
Angiotensin II Type 1 Receptor Blockers
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Vasoconstrictor Agents
Serine Proteinase Inhibitors
Angiotensin Receptor Antagonists