The Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
Recruitment status was: Recruiting
Abdominal aortic aneurysm (AAA) is a common disease that develops from degeneration of the aortic wall. The natural history of AAA is gradual expansion and if left untreated may result in rupture and death. The mechanism of the development of this disease is unknown however it appears to be multifactorial and possibly related to degradation processes within the arterial wall. There is growing evidence that Angiotensin receptor blockers ( ARBS) may have an inhibitory effect on remodelling processes within the arterial wall, thus inhibiting degeneration of the vessel wall.
Study hypothesis: ARBS are associated with smaller diameters of aortas among hypertensive patients, and are associated with a lower rate of aortic expansion compared to other antihypertensive drugs.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||the Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients|
|Study Start Date:||May 2011|
Hypertensive patients treated with ARBs
Hypertensive patients treated with ACE inhibitors
Hypertensive patients treated with non ARBs or ACE inhibitors meds
Please refer to this study by its ClinicalTrials.gov identifier: NCT01670903
|Sheba Medical Center|
|Tel Hashomer, Israel|
|Principal Investigator:||Daniel Silverberg, MD||Sheba Medical Center|