A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome
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This multi-center, non-drug study will explore the relationship between exploratory biomarkers and functional dimensions in male adult individuals with Autistic Disorder or Asperger's Syndrome and healthy volunteer controls. Subjects will undergo a number of assessments on study visit Day 1.
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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
High functioning (IQ >70) male adult individuals with Autistic Disorder or Asperger's Syndrome and age and IQ matched healthy male volunteers
Individuals with Autistic Disorder or Asperger's Syndrome:
Male adults, 18 to 45 years of age inclusive
Diagnosis of Autistic Disorder or Asperger's Syndrome as defined by DSM-IV
Body mass index (BMI) 18 to 35 kg/m2
Availability of a reliable caregiver, able and willing to provide information regarding the individual's behavior and symptoms
Healthy male adults, 18 to 45 years of age inclusive
Body mass index (BMI) 18 to 30 kg/m2
General exclusion criteria:
Positive test for drugs of abuse or alcohol
Confirmed systolic blood pressure >140 or <90 mmHg, and diastolic blood pressure >90 or <50 mmHg
Resting pulse rate >100 or <40 beats per minute
Alcohol and/or substance abuse/dependence during the last 12 months
Concomitant disease or condition that could interfere with, or treatment of which might interfere with, the conduct of the study, or that would, in the opinion of the investigator, pose an unacceptable risk to the subject in this study
Additionally for individuals with Autistic Disorder or Asperger's Syndrome:
History of epilepsy/seizure disorder (except simple febrile seizures)
Significant disruptive, aggressive or self-injurious, or sexually inappropriate behavior during the last 3 months that in the opinion of the investigator might interfere with the conduct of the study
Additionally for healthy controls:
Clinically significant abnormalities in laboratory test results
History of or current psychiatric, neurological disorder or pervasive developmental disorder