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Progranulin and CTRP3 in Metabolic Syndrome

This study has been completed.
Information provided by (Responsible Party):
K. M. Choi, Korea University Identifier:
First received: August 14, 2012
Last updated: August 16, 2012
Last verified: August 2012
Inflammation has been known to be a pivotal pathogenic mechanism of obesity-related disorders such as type 2 diabetes, metabolic syndrome and atherosclerosis. Adipose tissue functions as a major endocrine organ by adipokine mediated modulation of a number of signaling cascades in target tissues, that has pro-inflammatory or anti-inflammatory activities. Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to clarify the clinical meaning of these two adipokines in the subjects with or without metabolic syndrome

Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by K. M. Choi, Korea University:

Primary Outcome Measures:
  • Serum concentration of progranulin in the subjects with metabolic syndrome [ Time Frame: 12week ]
  • Serum concentration of CTRP3 in the subjects with metabolic syndrome [ Time Frame: 12week ]

Secondary Outcome Measures:
  • The relationship of serum progranulin levels with cardiovascular risk factors [ Time Frame: 12 week ]
  • The relationship of serum CTRP3 levels with cardiovascular risk factors [ Time Frame: 12 week ]

Enrollment: 127
Study Start Date: May 2012
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Apparently Helathy Subjects


Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.

Inclusion Criteria:

  • 20<age<80
  • apparently healthy subjects

Exclusion Criteria:

  • a history of CVD
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01668888

Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: K. M. Choi, Professor, Korea University Identifier: NCT01668888     History of Changes
Other Study ID Numbers: KoreaHealth_Progranulin
Study First Received: August 14, 2012
Last Updated: August 16, 2012

Additional relevant MeSH terms:
Metabolic Syndrome X
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases processed this record on August 18, 2017