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Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2012 by National Health Research Institutes, Taiwan.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
National Health Research Institutes, Taiwan Identifier:
First received: August 16, 2012
Last updated: August 17, 2012
Last verified: August 2012

Heroin addiction has emerged as a serious problem with tremendous impacts on the addicts and the society. Since the introduction of opioids substitutive treatment in 2006, more than 30,000 heroin addicts had received treatment, and nearly 12,000 continued on treatment currently. However, an unknown proportion of patients hidden in community remained un-treatment. To motivate the community heroin addicts is thus a challenging task.

It is suggested that decision making deficit is core feature which determine outcomes and treatment motivations in patients with addiction disorders. Recently, the state-of-the-art development of epigenetics uncover that environmental modification, via altering level of DNA methylation and gene expression will influence on neurocognitive functioning.

Via respondent-driven sampling, this study aims to recruit a representative sample targeting at the hard-to-reach community heroin addicts. The goal of this study is to identify the clinical feature as well as decision making-related neurocognitive deficit in these patients. Moreover, the investigators will explore the interplay of clinical features, DNA methylation and gene expressions on opioids receptor genes. The findings will help to clarify the clinical characteristics of community heroin addicts, to uncover the links between DNA methylation and clinical features of heroin addiction and to develop modifiable treatment targets in the future.

Heroin Addiction

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts

Resource links provided by NLM:

Further study details as provided by National Health Research Institutes, Taiwan:

Estimated Enrollment: 1
Study Start Date: August 2012
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)
community heroin addicts


Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
community heroin addicts

Inclusion Criteria:

  • 1) 20 to 65 of age; 2) meeting DSM-IV criteria of opioids dependence

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01668732

Contact: Sheng Chang Wang, M.D., M.Sc. 886-37-246166 ext 36703

Sponsors and Collaborators
National Health Research Institutes, Taiwan
Principal Investigator: Sheng Chang Wang, M.D., M.Sc. National Health Research Institute, Taiwan
  More Information

Responsible Party: National Health Research Institutes, Taiwan Identifier: NCT01668732     History of Changes
Other Study ID Numbers: MD101SCW01
Study First Received: August 16, 2012
Last Updated: August 17, 2012

Additional relevant MeSH terms:
Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents processed this record on May 24, 2017