Turner Syndrome Prenatal Diagnosis Study
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||National Collaborative Study of Girls Prenatally Diagnosed With Turner Syndrome Karyotypes|
- Number of signs of Turner syndrome [ Time Frame: three to six years ] [ Designated as safety issue: No ]Girls diagnosed with Turner syndrome by fetal ascertainment will have more signs of Turner syndrome than girls diagnosed by maternal ascertainment
- Growth [ Time Frame: three to six years ] [ Designated as safety issue: No ]Do girls with Turner syndrome ascertained by fetal ascertainment grow differently than girls ascertained by maternal ascertainment.
|Study Start Date:||January 2006|
|Estimated Study Completion Date:||January 2017|
|Estimated Primary Completion Date:||January 2017 (Final data collection date for primary outcome measure)|
Girls who are diagnosed with Turner syndrome because of concerns raised by an abnormal fetal ultrasound.
Girls who are diagnosed with Turner syndrome because their mothers had an amniocentesis for a reason other than an abnormal fetal ultrasound concerning for Turner syndrome. For example an amniocentesis was done because of advanced maternal age or because of an abnormal triple screen or because another condition was being screened for such as trisomy 21.
This is an observational study which will look at girls who are diagnosed with Turner syndrome before they are born. Girls will be divided into two groups: 1) those diagnosed because of features seen on ultrasound which raised the question of Turner syndrome and 2) those diagnosed incidentally when their mother had an amniocentesis for another reason such as advanced maternal age.
No clinical procedures nor interventions will be done as part of this data collection study which will occur for the first 3 to 6 years of the girl's life. The investigators will be looking to see if girls who are diagnosed incidentally have less features of Turner syndrome than those girls who are diagnosed because of fetal ultrasound.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01668251
|Contact: Patricia Fechner, MDfirstname.lastname@example.org|
|United States, Washington|
|Seattle Children's Hospital||Recruiting|
|Seattle, Washington, United States, 98105|
|Contact: Patricia Fechner, M.D. 800-317-7589 email@example.com|
|Contact: Sue Kearns, RN 1-206-987-1758 firstname.lastname@example.org|
|Principal Investigator: Patricia Fechner, MD|
|Principal Investigator:||Patricia Fechner, MD||Seattle Children's|