The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||The Optimized Diagnostic Methods for the Confirmation of Penicillin/Aminopenicillin Allergy in Thailand|
- The true prevalence of drug allergy in patients with a history of penicillin/aminopenicillin allergy [ Time Frame: 1 year ] [ Designated as safety issue: No ]The skin test positive rate in patients with a history of penicillin/aminopenicillin allergy determined by standard skin test reagents
- Clinical values of various diagnostic modalities in patients with a history of penicillin/aminopenicillin allergy [ Time Frame: 1 year ] [ Designated as safety issue: No ]The diagnostic values of skin testing, drug-specific IgE measurement, and interferon-gamma ELISpot assay for the diagnosis of penicillin/aminopenicillin allergy
Biospecimen Retention: Samples Without DNA
|Study Start Date:||November 2012|
|Study Completion Date:||July 2016|
|Primary Completion Date:||July 2016 (Final data collection date for primary outcome measure)|
Patients with suspected drug allergy
Patients with a history of allergic reaction to penicillin/aminopenicillin
Patients with a history of penicillin/aminopenicillin allergy will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable).
Diagnostic values of the measurement of specific IgE to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01667055
|Bangkok, Thailand, 10330|
|Principal Investigator:||Jettanong Klaewsongkram, MD||Chulalongkorn University|