The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand
|ClinicalTrials.gov Identifier: NCT01667055|
Recruitment Status : Completed
First Posted : August 17, 2012
Last Update Posted : July 27, 2016
|Condition or disease|
|Penicillin Allergy Aminopenicillin Allergy|
Patients with a history of penicillin/aminopenicillin allergy will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable).
Diagnostic values of the measurement of specific IgE to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
|Study Type :||Observational|
|Actual Enrollment :||160 participants|
|Official Title:||The Optimized Diagnostic Methods for the Confirmation of Penicillin/Aminopenicillin Allergy in Thailand|
|Study Start Date :||November 2012|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
Patients with suspected drug allergy
Patients with a history of allergic reaction to penicillin/aminopenicillin
- The true prevalence of drug allergy in patients with a history of penicillin/aminopenicillin allergy [ Time Frame: 1 year ]The skin test positive rate in patients with a history of penicillin/aminopenicillin allergy determined by standard skin test reagents
- Clinical values of various diagnostic modalities in patients with a history of penicillin/aminopenicillin allergy [ Time Frame: 1 year ]The diagnostic values of skin testing, drug-specific IgE measurement, and interferon-gamma ELISpot assay for the diagnosis of penicillin/aminopenicillin allergy
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01667055
|Bangkok, Thailand, 10330|
|Principal Investigator:||Jettanong Klaewsongkram, MD||Chulalongkorn University|