The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand
The true prevalence of drug allergy in patients with a history of penicillin/aminopenicillin allergy will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||The Optimized Diagnostic Methods for the Confirmation of Penicillin/Aminopenicillin Allergy in Thailand|
- The true prevalence of penicillin/aminopenicillin allergy [ Time Frame: 1 year ] [ Designated as safety issue: No ]The skin test positive rate in patients with a history of penicillin/aminopenicillin allergy determined by standard skin test reagents
- The diagnostic values of currently used skin test reagents and drug-specific IgE measurement [ Time Frame: 1 year ] [ Designated as safety issue: No ]The sensitivity of currently used skin test reagents in Thailand and penicilloyl/amoxicilloyl-specific IgE compared to the standard skin test reagents for the diagnosis of penicillin/aminopenicillin allergy
Biospecimen Retention: Samples With DNA
|Study Start Date:||November 2012|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||November 2015 (Final data collection date for primary outcome measure)|
Patients with suspected drug allergy
Patients with a history of an immediate reaction to penicillin or aminopenicillin allergy
Patients with a history of an immediate reaction to penicillin/aminopenicillin will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable).
Diagnostic values of the measurement of specific IgE to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01667055
|Contact: Jettanong Klaewsongkram, MD||02-2564152||Jettanong.K@chula.ac.th|
|Bangkok, Thailand, 10330|
|Contact: Jettanong Klaewsongkram, MD 02-2564152 Jettanong.K@chula.ac.th|
|Principal Investigator: Jettanong Klaewsongkram, MD|
|Principal Investigator:||Jettanong Klaewsongkram, MD||Chulalongkorn University|