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Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

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ClinicalTrials.gov Identifier: NCT01665729
Recruitment Status : Unknown
Verified August 2012 by Li Haiyan, Third Affiliated Hospital, Sun Yat-Sen University.
Recruitment status was:  Recruiting
First Posted : August 15, 2012
Last Update Posted : August 15, 2012
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important.

The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.


Condition or disease
Ischaemic Stroke

Study Design

Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
Study Start Date : June 2011
Primary Completion Date : August 2012
Estimated Study Completion Date : December 2015
Groups and Cohorts

Group/Cohort
artery-artery embolus
There is no hypoperfusion ( contralateral compensatory is good )
Hypoperfusion
Contralateral compensatory not sufficient
Hypoperfusion and embolus amotic
Hypoperfusion and embolus amotic


Outcome Measures

Eligibility Criteria

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Ages Eligible for Study:   20 Years to 79 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with new emergence of minor ischaemic stroke ( one of two conditions: (1) conscious patients with any of NIHSS score = 1,or (2) NIHSS ≤ 3 )
Criteria

Inclusion Criteria:

one of two conditions:

  1. conscious patients with any of NIHSS score = 1,or
  2. NIHSS ≤ 3

Exclusion Criteria:

  • patients Over 80 years of age
  • patients With serious heart, lung, liver, kidney dysfunction or
  • severe systemic complications,
  • a known tumor,
  • pregnancy,
  • having a history of cerebral hemorrhage
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01665729


Contacts
Contact: Zhengqi Lu, prof. 86 13570102668 lzq1828@yahoo.com.cn
Contact: Haiyan Li, Dr. 86 15920474159 lihaiyan162@yahoo.com.cn

Locations
China, Guangdong
Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University Recruiting
Guangzhou, Guangdong, China, 510630
Contact: Zhengqi Lu, prof.    86 13570102668    lzq1828@yahoo.com.cn   
Contact: Haiyan Li    86 15920474159    lihaiyan162@yahoo.com.cn   
Principal Investigator: Zhengqi Lu, prof.         
Sponsors and Collaborators
Li Haiyan
Investigators
Study Chair: Zhengqi Lu, prof. Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University
More Information

Responsible Party: Li Haiyan, Dr., Third Affiliated Hospital, Sun Yat-Sen University
ClinicalTrials.gov Identifier: NCT01665729     History of Changes
Other Study ID Numbers: 2011-2-48
First Posted: August 15, 2012    Key Record Dates
Last Update Posted: August 15, 2012
Last Verified: August 2012

Keywords provided by Li Haiyan, Third Affiliated Hospital, Sun Yat-Sen University:
etiology
pathogenesis
minor ischaemic stroke
types
intervention

Additional relevant MeSH terms:
Stroke
Ischemia
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Pathologic Processes
Brain Infarction
Brain Ischemia