Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
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ClinicalTrials.gov Identifier: NCT01665300
Recruitment Status :
First Posted : August 15, 2012
Last Update Posted : April 29, 2014
Seoul National University Hospital
Information provided by (Responsible Party):
Hyung-Kwan Kim, Seoul National University Hospital
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial dysfunction because of the risk of heart failure with this treatment. Myocardial deformation imaging is a sensitive means of detecting LV dysfunction, but this technique has not been evaluated in patients treated with trastuzumab. The aim of this study was to investigate whether changes in tissue deformation, assessed by myocardial strain and strain rate (SR), are able to identify LV dysfunction earlier than conventional echocardiographic measures in patients treated with trastuzumab.
Condition or disease
Left Ventricular Function Systolic DysfunctionCardiotoxicity
The investigators will prospectively evaluate whether changes in tissue deformation, assessed by myocardial strain and strain rate (SR) and identify possibility of early detection of LV dysfunction in patients treated with trastuzumab.
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The investigators evaluated serial echocardiograms (baseline, 3, 6, 9, and 12 months)from 120 consecutive female patients receiving trastuzumab as part of their treatment for either early or advanced breast cancer.
HER2(+) breast cancer, anticipating Trastuzumab therapy
Refusal to informed consent
Congenital heart disease
Significant arrhythmia in EKG
Regional wall motion abnormality (+) in echocardiography