Internalized Stigma in Patients With Bipolar Disorder or Schizophrenia (ESTINT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01664884
Recruitment Status : Unknown
Verified August 2012 by Ricardo Alberto Moreno, M.D., Ph.D., University of Sao Paulo.
Recruitment status was:  Recruiting
First Posted : August 14, 2012
Last Update Posted : August 16, 2012
Information provided by (Responsible Party):
Ricardo Alberto Moreno, M.D., Ph.D., University of Sao Paulo

Brief Summary:
The aim of this study is to explore the levels of internalized stigma in a sample of young patients with bipolar disorder or schizophrenia.

Condition or disease

Detailed Description:

The stigma is considered by patients, government organizations and health professionals a key point in mental illness (Griffiths et al, 2006). The related literature has focused on individuals with schizophrenia although there are indications that stigma act negatively in patients with bipolar disorder; this, in turn, is described in a few studies, always with heterogeneous samples, chronic and symptomatic patients (Perlick et al, 2001). It is also known that there is a significant association between affective symptoms and the presence of stigma, (Vázquez et al, 2010).

There are reports of higher levels of public stigma towards people with schizophrenia, compared to patients with bipolar disorder or unipolar depression, however there are no studies available on internalized stigma in such samples, especially in remitted patients . Since schizophrenia coexists with significant impairment of insight, such individuals may exhibit more difficulty internalizing the external bias and stereotypes. On the other hand, patients with bipolar disorder - despite being less discriminated by the public in relation to schizophrenia - probably have a high potential for self-stigma and its fearsome consequences, justified by higher levels of insight.

The investigators would like to examine whether the lower impairment of insight in young bipolar patients(in relation to young people with schizophrenia) could be accompanied by an increase in internalized stigma in this sample. It´s an observational, cross-sectional study with no intervention.

Hypothesis: the internalized stigma in young adults with bipolar disorder is identical to that of young patients with schizophrenia.

Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Internalized Stigma in a Sample of Young Adults With Bipolar Disorder or Schizophrenia.
Study Start Date : June 2012
Estimated Primary Completion Date : January 2013
Estimated Study Completion Date : January 2013

Resource links provided by the National Library of Medicine

Bipolar Disorder Patients
Bipolar Disorder Patients, with age between 18 to 40 years old, at euthymic phase.
Schizophrenia Patients
Schizophrenia Patients, with age between 18 to 40 years old, with minimum or none positive symptoms.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The group will consist of patients from the Institute of Psychiatry, Hospital das Clinicas, Faculty of Medicine, University of São Paulo (HCFMUSP) diagnosed by DSM-IV-TR bipolar disorder (in remission) or schizophrenia (absence of positive symptoms).

Inclusion Criteria:

  • Diagnosis of bipolar disorder and schizophrenia according to DSM-IV-TR, presenting in euthymia (bipolar disorder) or without positive symptoms (schizophrenia), based on clinical assessment and confirmed by structured clinical interview SCID-P
  • Age between 18 and 40 years
  • Literate and able to understand the tasks required.
  • Residents of Greater Sao Paulo.
  • Patients and / or legal representatives must understand the nature of the study and sign an informed consent.

Exclusion Criteria:

  • Patients with Schizoaffective Disorder or Mental Retardation.
  • Unstable serious diseases including kidney disease, gastroenterology, respiratory, cardiovascular, endocrine, neurological, immunological or haematological.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01664884

Contact: Luis Felipe Oliveira Costa, M.D. +551198053654

PROGRUDA-Institute of Psychiatry- HCFMUSP Recruiting
Sao Paulo, SP, Brazil
Contact: Nayara Rodrigues, Secretary    +551126616648   
Sub-Investigator: Luis Felipe de Oliveira Costa, MD         
Sponsors and Collaborators
University of Sao Paulo
Study Director: Ricardo Alberto Moreno, MD PhD University of Sao Paulo

Responsible Party: Ricardo Alberto Moreno, M.D., Ph.D., Ricardo Alberto Moreno, University of Sao Paulo Identifier: NCT01664884     History of Changes
Other Study ID Numbers: ESTINT
First Posted: August 14, 2012    Key Record Dates
Last Update Posted: August 16, 2012
Last Verified: August 2012

Keywords provided by Ricardo Alberto Moreno, M.D., Ph.D., University of Sao Paulo:

Additional relevant MeSH terms:
Bipolar Disorder
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Bipolar and Related Disorders