International Plastic Bronchitis Registry
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|ClinicalTrials.gov Identifier: NCT01663948|
Recruitment Status : Terminated (Loss of staff combined with low study enrollment and a change in lab/PI priorities)
First Posted : August 14, 2012
Last Update Posted : March 11, 2020
|Condition or disease|
Plastic bronchitis (PB) patients have casts removed during bronchoscopy as part of their routine care or that they are able to expectorate (cough out) casts naturally. The casts are normally discarded. Patients that agree to participate in the registry ship the airway casts and medical history to Dr. Bruce Rubin's Research Laboratory at Virginia Commonwealth University Richmond Virginia, USA.
The lab evaluates the biopolymer composition and structure of the airway casts by immunohistochemistry in order to identify microscopic differences between expectorated casts of subjects with plastic bronchitis and sputum from other populations (cystic fibrosis,chronic obstructive pulmonary disease , and normal airways). The lab also conducts in vitro evaluation of clearability, adhesivity, cohesivity, and inflammatory mediator concentrations to better understand the nature of the disease.
|Study Type :||Observational|
|Actual Enrollment :||23 participants|
|Official Title:||International Plastic Bronchitis Registry|
|Study Start Date :||July 2012|
|Actual Primary Completion Date :||November 1, 2018|
|Actual Study Completion Date :||November 1, 2018|
|Patients with Plastic bronchitis|
- natural course and long term health outcomes [ Time Frame: ongoing ]The purpose of the intrnational plastic bronchitis registry is to understand the natural course and long term health outcomes of patients diagnosed with plastic bronchitis. This provides essential data for identifying possible causes of this disease and potential treatments.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01663948
|United States, Virginia|
|Virginia Commonwealth University|
|Richmond, Virginia, United States, 23298|
|Principal Investigator:||Bruce K Rubin, MEngr, MD, MBA, FRCPC||Children's Hospital of Richmond at VCU|