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Optical Biometry and Spherical Aberration in Ametropic and Emmetropic Eyes

This study has been completed.
Information provided by (Responsible Party):
Gerhard Garhofer, Medical University of Vienna Identifier:
First received: August 9, 2012
Last updated: August 28, 2013
Last verified: August 2013

Aberrations play a significant role in the visual process and can be divided in lower-order and higher-order aberrations. The former can be measured using the commercially available IOL Master (Carl Zeiss Meditec AG, Germany) and have profound influence on visual acuity. Higher-order aberrations do not significantly influence visual acuity but affect the quality of vision and can cause halos, double vision, and night vision disturbances.

Background Cataract surgery has become a routine procedure in the developed countries. During this surgery, a foldable intraocular lens is usually inserted into the capsular bag. However, these lenses do not account for individual optical biometry data or aberrations. Therefore, it is important to provide data for ametropic and emmetropic eyes as this information might improve future intraocular lens design and lead to individually adapted lenses for yielding optimal visual acuity and quality results.

The aim of the present study is to clarify the correlation between refractive errors/axial eye length and spherical aberrations of the cornea.

Refractive Errors
Axial Length, Eye
Corneal Wavefront Aberration

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Optical Biometry and Spherical Aberration in Ametropic and Emmetropic Eyes

Resource links provided by NLM:

Further study details as provided by Gerhard Garhofer, Medical University of Vienna:

Primary Outcome Measures:
  • Axial eye length [ Time Frame: 1 day ]

Secondary Outcome Measures:
  • Refractive error [ Time Frame: 1 day ]
  • Corneal radius [ Time Frame: 1 day ]
  • Pupil diameter [ Time Frame: 1 day ]
  • Anterior chamber depth [ Time Frame: 1 day ]
  • Anterior corneal topography [ Time Frame: 1 day ]
  • Corneal thickness map [ Time Frame: 1 day ]

Enrollment: 160
Study Start Date: August 2012
Study Completion Date: May 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Cohort 1
40 subjects with high grarde myopia ranging from -10 diopters to -4.01 diopters
Cohort 2
40 subjects with moderate myopia ranging from -4 diopters to -1.01 diopter
Cohort 3
40 subjects with emmetropia, -1 diopter to +1 diopter
Cohort 4
40 subjects with hyperopia, +1.01 diopter and more


Ages Eligible for Study:   40 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The participants will be selected by the Department of Clinical Pharmacology

Inclusion Criteria:

  • men and women aged between 40 and 60 years
  • normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
  • normal ophthalmic findings unless the investigator considers an abnormality to be clinically irrelevant

Exclusion Criteria:

  • presence of any corneal or retinal disease
  • Dry eye syndrome
  • high astigmatism (>1 diopter)
  • history of refractive surgery
  • abuse of alcoholic beverages
  • participation in a clinical trial in the 3 weeks preceding the study
  • symptoms of a clinically relevant illness in the 3 weeks before the study day
  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01663597

Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090
Sponsors and Collaborators
Medical University of Vienna
  More Information

Responsible Party: Gerhard Garhofer, Assoc. Prof. Priv. Doz. Dr., Medical University of Vienna Identifier: NCT01663597     History of Changes
Other Study ID Numbers: OPHTH-240512
Study First Received: August 9, 2012
Last Updated: August 28, 2013

Additional relevant MeSH terms:
Refractive Errors
Corneal Wavefront Aberration
Eye Diseases
Corneal Diseases processed this record on May 25, 2017