The Effect of Calorie Deprivation on Adipose Tissue Distribution
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ClinicalTrials.gov Identifier: NCT01658397
Recruitment Status :
First Posted : August 7, 2012
Last Update Posted : February 10, 2017
Massachusetts General Hospital
Information provided by (Responsible Party):
Pouneh K. Fazeli, MD, Massachusetts General Hospital
In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters. We will be measuring changes in bone marrow fat using magnetic resonance spectroscopy and will use MRI to measure subcutaneous and visceral fat depots. Our hypothesis is that levels of bone marrow fat will increase after an acute fast.
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Ages Eligible for Study:
21 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Men and women, ages 21-45 years
101-130% of ideal body weight as defined by the 1983 Metropolitan Life Insurance Height and Weight Tables
Normal thyroid function
Regular menses (women)
Normal liver transaminases
Any disease known to affect bone metabolism, including untreated thyroid dysfunction, Cushing's syndrome, or renal failure
Any medication known to affect bone metabolism -- including systemic steroids or immunosuppressants -- within three months of the study, excluding estrogen and progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be excluded from participating for six months after their last injections. Bisphosphonates must have been discontinued for at least one year before participation
Serum potassium <3.0 meq/L
Pregnant and/or breastfeeding (women)
Active substance abuse, including alcohol
Contraindications to MRI: cardiac pacemaker, metal implants, claustrophobia