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Rate Control in Atrial Fibrillation

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ClinicalTrials.gov Identifier: NCT01655303
Recruitment Status : Completed
First Posted : August 1, 2012
Last Update Posted : August 1, 2012
Sponsor:
Information provided by (Responsible Party):
Tehran University of Medical Sciences

Brief Summary:

Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments.

This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.


Condition or disease Intervention/treatment Phase
Rapid Ventricular Response Atrial Fibrillation Drug: Propranolol Drug: Metoprolol Drug: Verapamil Drug: Diltiazem Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 90 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: Oral Propranolol, Diltiazem, Metoprolol and Verapamil in Atrial Fibrillation Rate Control in Patients With Stable Hemodynamic Status
Study Start Date : February 2011
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011


Arm Intervention/treatment
Experimental: Metoprolol Per Oral
50 mg Metoprolol
Drug: Metoprolol
Other Name: Metoral
Experimental: Verapamil
40 mg Verapamil Per Oral
Drug: Verapamil
Experimental: Propranolol
40 mg Propranolol Per Oral
Drug: Propranolol
Other Name: Inderal
Experimental: Diltiazem
60 mg Diltiazem Per Oral
Drug: Diltiazem



Primary Outcome Measures :
  1. Rate less than 100 per minute [ Time Frame: In 1 hour ]
    Ventricular rate less than 100 per minute after 1 hour of per oral medication administration


Secondary Outcome Measures :
  1. Drugs adverse effects [ Time Frame: 2 hours ]
    Drugs adverse effects seen in patients in 2 hours after per oral medication administration

  2. Unstability in hemodynamic [ Time Frame: 2 hours ]
    Hemodynamic instability (systolic blood pressure less than 90 mmHg, loss of consciousness, pulmonary edema, chest pain)



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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age more than 18 years old
  • Stability in hemodynamic

Exclusion Criteria:

  • Systolic blood pressure less than 90 mm Hg
  • Altered mental status attributable to rapid ventricular response atrial fibrillation
  • Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation
  • Chest pain attributable to rapid ventricular response atrial fibrillation
  • Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem
  • History of asthma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01655303


Locations
Iran, Islamic Republic of
Rasoul-e-Akram Hospital
Tehran, Iran, Islamic Republic of, 14436151
Sponsors and Collaborators
Tehran University of Medical Sciences

Responsible Party: Tehran University of Medical Sciences
ClinicalTrials.gov Identifier: NCT01655303     History of Changes
Other Study ID Numbers: 16057
First Posted: August 1, 2012    Key Record Dates
Last Update Posted: August 1, 2012
Last Verified: July 2012

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Propranolol
Metoprolol
Verapamil
Diltiazem
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Antihypertensive Agents
Vasodilator Agents
Sympatholytics
Autonomic Agents
Peripheral Nervous System Agents
Adrenergic beta-1 Receptor Antagonists
Calcium Channel Blockers
Membrane Transport Modulators