Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients (HITOLT)

This study has been completed.
University Medicine Greifswald
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: March 30, 2012
Last updated: July 31, 2012
Last verified: July 2012
In a prospective observational study the incidence of Heparin-induced Thrombocytopenia (HIT) Type 2 after orthotopic liver transplantation, associated factors, and hemostaseological findings in thrombocytes and anti-body patterns is going to be investigated.

Heparin-induced Thrombocytopenia
Liver Transplantation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients: a Prospective Multivariate Analysis of Prognostic Factors and Haemostaseological Findings

Resource links provided by NLM:

Further study details as provided by CHIR-Net:

Enrollment: 39
Study Start Date: January 2010
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
orthotopic Liver Transplantation
consecutive inclusion of all recipients

Detailed Description:
The investigators examined the frequency of anti-PF4/heparin antibodies (IgG/M/A; EIA) and their functional activity (HIPA) in 38 whole organ deceased donor liver transplant recipients. Additionally, demographic, clinical, donor- and recipient-specific parameters and laboratory findings (ALAT, ASAT, cholinesterase) were investigated.

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
consecutive livertransplant recipients of our transplant center, organ allocation via Eurotransplant Foundation, Leiden, The Netherlands; Laboratory investigations performed at the Abteilung für Transfusionsmedizin am Institut für Immunologie und Transfusionsmedizin der Universitätsmedizin Greifswald, Greifswald, Germany

Inclusion Criteria:

  • all consecutive liver transplant recipients between 01/2010 and 08/2011 who
  • were transplanted at our center after allocation of a liver graft via Eurotransplant

Exclusion Criteria:

  • patient's refusal to participate in prospective observation
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01654848

Klinikum rechts der Isar der TU München
Munich, Germany, D-81675
Sponsors and Collaborators
University Medicine Greifswald
Principal Investigator: Volker Assfalg, MD Klinikum rechts der Isar, Dept. of Surgery
  More Information

No publications provided

Responsible Party: CHIR-Net
ClinicalTrials.gov Identifier: NCT01654848     History of Changes
Other Study ID Numbers: TransplanTUM-1, HITafterOLT
Study First Received: March 30, 2012
Last Updated: July 31, 2012
Health Authority: Germany: Ethics Commission

Keywords provided by CHIR-Net:
liver transplantation
heparin-induced thrombocytopenia
multivariate analysis of associated factors of HIT 2 after OLT
laboratory investigations of HIT-antibodies

Additional relevant MeSH terms:
Blood Platelet Disorders
Hematologic Diseases

ClinicalTrials.gov processed this record on November 27, 2015